Prognostic biomarkers in oral squamous cell carcinoma: A systematic review

被引：126

作者：

Rivera, Cesar ^{[1
,2
,3
]}

Oliveira, Ana Karina ^{[1
,3
]}

Pereira Costa, Rute Alves ^{[1
]}

De Rossi, Tatiane ^{[1
,4
]}

Paes Leme, Adriana Franco ^{[1
]}

机构：

[1] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biosci Natl Lab LNBio, Sao Paulo, Brazil

[2] Univ Talca UTALCA, Fac Hlth Sci, Dept Biomed Sci, Talca, Maule Region, Chile

[3] Univ Campinas UNICAMP, Piracicaba Dent Sch, Dept Oral Diag, Sao Paulo, Brazil

[4] Univ Campinas UNICAMP, Inst Biol, Funct & Mol Biol Grad Program, Sao Paulo, Brazil

来源：

ORAL ONCOLOGY | 2017年 / 72卷

基金：

巴西圣保罗研究基金会;

关键词：

Mouth neoplasms; Oral cancer; Oral squamous cell carcinoma; Biomarkers; tumor; Review; Systematic; LYMPH-NODE METASTASIS; CARBONIC-ANHYDRASE-IX; POOR-PROGNOSIS; STAGE-I; PODOPLANIN EXPRESSION; RISK STRATIFICATION; PREDICTIVE MARKER; HEME OXYGENASE-1; KI-67; EXPRESSION; CANCER-RISK;

D O I：

10.1016/j.oraloncology.2017.07.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, diseasefree survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：38 / 47

页数：10

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