Epigenetic mechanisms in endometrial cancer

被引：5

作者：

Stampoliou, Albiona ^{[1
,2
]}

Arapantoni-Dadioti, Petroula ^{[3
]}

Pavlakis, Kitty ^{[4
]}

机构：

[1] Univ Athens, Sch Med, MSc Programme Res Female Reprod, GR-11527 Athens, Greece

[2] TEI Athens, Midwifery Dept, Athens, Greece

[3] Metaxa Canc Hosp, Dept Pathol, Piraeus, Greece

[4] Univ Athens, Sch Med, Pathol Dept, GR-11527 Athens, Greece

来源：

JOURNAL OF BUON | 2016年 / 21卷 / 02期

关键词：

endometrial cancer; endometrioid; epigenetic; methylation; DNA METHYLATION PATTERNS; PROMOTER HYPERMETHYLATION; MICROSATELLITE INSTABILITY; CARCINOMA; GENES; EXPRESSION; MUTATIONS; CARCINOGENESIS; HYPERPLASIA; EPIGENOMICS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: Endometrial cancer is a very common type of cancer in females worldwide. Advances in diagnosis and treatment have not decreased the incidence of endometrial cancer. Lately, research has been focused on revealing the molecular and genetic characteristics of endometrial cancer in order to provide new insights in the biology of this entity, leading hopefully to innovating therapies. Research has revealed that epigenetic modifications govern endometrial carcinogenesis. In this review, the epigenetic mechanisms that are involved in endometrial cancer as well as the differences between the different types of endometrial cancer are discussed. The review also refers to the putative therapeutic benefits that hopefully can arise.

引用

页码：301 / 306

页数：6

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