Roles of natural killer cells in antiviral immunity

被引：110
作者：
Waggoner, Stephen N. [1 ,2 ,3 ,4 ]
Reighard, Seth D. [1 ,2 ,3 ]
Gyurova, Ivayla E. [1 ,4 ]
Cranert, Stacey A. [1 ]
Mahl, Sarah E. [1 ]
Karmele, Erik P. [1 ]
McNally, Jonathan P. [1 ]
Moran, Michael T. [1 ,2 ]
Brooks, Taylor R. [1 ]
Yaqoob, Fazeela [1 ,2 ]
Rydyznski, Carolyn E. [1 ,2 ]
机构：
[1] Cincinnati Childrens Hosp Med Ctr, CAGE, Cincinnati, OH 45229 USA
[2] Univ Cincinnati, Immunol Grad Program, Cincinnati, OH USA
[3] Univ Cincinnati, Med Scientist Training Program, Cincinnati, OH USA
[4] Univ Cincinnati, Pathobiol & Mol Med Grad Program, Cincinnati, OH USA
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 16卷
基金：
美国国家卫生研究院;
关键词：
VESICULAR STOMATITIS-VIRUS; CD8(+) T-CELLS; NK CELLS; CYTOMEGALOVIRUS-INFECTION; MEDIATED INHIBITION; INNATE PROTECTION; IL-10; PRODUCTION; LETHAL MOUSEPOX; HIV-1; INFECTION; DENDRITIC CELLS;
D O I：
10.1016/j.coviro.2015.10.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Natural killer (NK) cells are important in immune defense against virus infections. This is predominantly considered a function of rapid, innate NK-cell killing of virus-infected cells. However, NK cells also prime other immune cells through the release of interferon gamma (IFN-gamma) and other cytokines. Additionally, NK cells share features with long-lived adaptive immune cells and can impact disease pathogenesis through the inhibition of adaptive immune responses by virus-specific T and B cells. The relative contributions of these diverse and conflicting functions of NK cells in humans are poorly defined and likely context-dependent, thereby complicating the development of therapeutic interventions. Here we focus on the contributions of NK cells to disease in diverse virus infections germane to human health.
引用
收藏
页码：15 / 23
页数：9
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