Immune-related genes with APA in microenvironment indicate risk stratification and clinical prognosis in grade II/III gliomas

被引：22

作者：

Xu, Shengchao ^{[1
]}

Tang, Lu ^{[2
]}

Dai, Gan ^{[3
]}

Luo, Chengke ^{[1
]}

Liu, Zhixiong ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Neurosurg, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Dept Thorac Surg, Changsha 410008, Hunan, Peoples R China

[3] Cent South Univ, Xiangya Sch Med, Dept Microbiol, Changsha 410008, Hunan, Peoples R China

来源：

MOLECULAR THERAPY-NUCLEIC ACIDS | 2021年 / 23卷

基金：

中国国家自然科学基金;

关键词：

ALTERNATIVE CLEAVAGE; POLYADENYLATION; MANAGEMENT;

D O I：

10.1016/j.omtn.2021.01.033

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Tumor microenvironment and alternative polyadenylation (APA) have drawn more attention in cancer research. However, their roles in grade II and III gliomas, termed as lower-grade glioma (LGG) in this study, remain to be fully elucidated. Here, we conducted this study and found that stromal and immune scores were elevated in higher grade and isocitrate dehydrogenase (IDH) wild-type glioma. Besides, higher stromal and immune scores indicated a poor prognosis in patients with LGG. APA events in immune-related genes were associated with overall survival, RNA expression, IDH mutation, and disease-free survival. Patients in the high-risk group had poor prognoses, and the risk score could be used to predict the survival rate. The risk score was positively correlated with the expression of immune checkpoints, inflammatory cytokines, and infiltrated immune cells. Moreover, risk stratification could predict the efficacy of radiotherapy and provide a reference for the treatment of grade III glioma. Our study revealed that immune-related genes with APA events in the microenvironment could predict risk stratification and clinical prognosis in patients with LGG.

引用

页码：1229 / 1242

页数：14

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