The Varicella-Zoster Virus Genome

被引：53

作者：

Cohen, Jeffrey I. ^{[1
]}

机构：

[1] NIH, Lab Clin Infect Dis, Bethesda, MD 20892 USA

来源：

VARICELLA-ZOSTER VIRUS | 2010年 / 342卷

关键词：

BACTERIAL ARTIFICIAL CHROMOSOME; LATENCY-ASSOCIATED PROTEIN; OPEN READING FRAME-62; REPLICATION IN-VITRO; INSULIN DEGRADING ENZYME; VIRAL REPLICATION; MUTATIONAL ANALYSIS; GLYCOPROTEIN I; HUMAN SKIN; CELL-CULTURE;

D O I：

10.1007/82_2010_10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The varicella-zoster virus (VZV) genome contains at least 70 genes, and all but six have homologs in herpes simplex virus (HSV). Cosmids and BACs corresponding to the VZV parental Oka and vaccine Oka viruses have been used to "knockout" 34 VZV genes. Seven VZV genes (ORF4, 5, 9, 21, 29,62, and 68) have been shown to be required for growth in vitro. Recombinant viruses expressing several markers (e.g., beta-galactosidase, green fluorescence protein, luciferase) and several foreign viral genes (from herpes simplex, Epstein Barr virus, hepatitis B, mumps, HIV, and simian immunodeficiency virus) have been constructed. Further studies of the VZV genome, using recombinant viruses, may facilitate the development of safer and more effective VZV vaccines. Furthermore, VZV might be useful as a vaccine vector to immunize against both VZV and other viruses.

引用

页码：1 / 14

页数：14

共 65 条

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