High dose bystander effects in spatially fractionated radiation therapy

被引：112

作者：

Asur, Rajalakshmi ^{[1
]}

Butterworth, Karl T. ^{[2
]}

Penagaricano, Jose A. ^{[1
]}

Prise, Kevin M. ^{[2
]}

Griffin, Robert J. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Dept Radiat Oncol, Little Rock, AR 72205 USA

[2] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland

来源：

CANCER LETTERS | 2015年 / 356卷 / 01期

关键词：

GRID; IMRT; Bystander effects; Spatially fractionated radiation therapy; ALPHA-PARTICLES; GENE-EXPRESSION; GRID RADIATION; IN-VITRO; CARCINOMA-CELLS; GLIOMA-CELLS; TUMOR-CELLS; CANCER; RESPONSES; FIBROBLASTS;

D O I：

10.1016/j.canlet.2013.10.032

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Traditional radiotherapy of bulky tumors has certain limitations. Spatially fractionated radiation therapy (GRID) and intensity modulated radiotherapy (IMRT) are examples of advanced modulated beam therapies that help in significant reductions in normal tissue damage. GRID refers to the delivery of a single high dose of radiation to a large treatment area that is divided into several smaller fields, while IMRT allows improved dose conformity to the tumor target compared to conventional three-dimensional conformal radiotherapy. In this review, we consider spatially fractionated radiotherapy approaches focusing on GRID and IMRT, and present complementary evidence from different studies which support the role of radiation induced signaling effects in the overall radiobiological rationale for these treatments. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：52 / 57

页数：6

共 69 条

[1] Novel action of paclitaxel against cancer cells: Bystander effect mediated by reactive oxygen species [J].

Alexandre, Jerome ;

Hu, Yumin ;

Lu, Weiqin ;

Pelicano, Helene ;

Huang, Peng .

CANCER RESEARCH, 2007, 67 (08) :3512-3517

[2]

Aneja S, 2012, ONCOLOGY-NY, V26, P512

[3] Spatially Fractionated Radiation Induces Cytotoxicity and Changes in Gene Expression in Bystander and Radiation Adjacent Murine Carcinoma Cells [J].

Asur, Rajalakshmi S. ;

Sharma, Sunil ;

Chang, Ching-Wei ;

Penagaricano, Jose ;

Kommuru, Indira M. ;

Moros, Eduardo G. ;

Corry, Peter M. ;

Griffin, Robert J. .

RADIATION RESEARCH, 2012, 177 (06) :751-765

[4] Chemical induction of the bystander effect in normal human lymphoblastoid cells [J].

Asur, Rajalakshmi S. ;

Thomas, Robert A. ;

Tucker, James D. .

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2009, 676 (1-2) :11-16

[5] Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect [J].

Azzam, EI ;

de Toledo, SM ;

Little, JB .

ONCOGENE, 2003, 22 (45) :7050-7057

[6] Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from α-particle irradiated to nonirradiated cells [J].

Azzam, EI ;

de Toledo, SM ;

Little, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (02) :473-478

[7]

Barcellos-Hoff MH, 2001, RADIAT RES, V156, P618, DOI 10.1667/0033-7587(2001)156[0618:ESTTMA]2.0.CO

[8]

[9]

BECKER J, 1965, Prog Radiat Ther, V3, P50

[10] Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures? [J].

Blyth, Benjamin J. ;

Sykes, Pamela J. .

RADIATION RESEARCH, 2011, 176 (02) :139-157

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