Synthesis of the 2α-benzoylamido analogue of docetaxel

被引：10

作者：

Fang, WS ^{[1
]}

Fang, QC

Liang, XT

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 07期

关键词：

paclitaxel; docetaxel; 2-benzoylamido analogue of docetaxel; S(N)2 double inversion;

D O I：

10.1016/S0040-4039(00)02243-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 2 alpha -benzoylamido analogue of docetaxel 2 was synthesized with a double inversion of the C-2 configuration as the key step, and its cytotoxic activity towards three tumor cell lines was tested. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1331 / 1333

页数：3

共 20 条

[11] SYNTHESIS OF BIOLOGICALLY-ACTIVE 2-BENZOYL PACLITAXEL ANALOGS [J].

GEORG, GI ;

ALI, SM ;

BOGE, TC ;

DATTA, A ;

FALBORG, L ;

PARK, H ;

MEJILLANO, M ;

HIMES, RH .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (03) :259-264

[12]

Gomez Paloma L, 1994, Chem Biol, V1, P107

[13] Protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III [J].

Holton, RA ;

Zhang, ZM ;

Clarke, PA ;

Nadizadeh, H ;

Procter, DJ .

TETRAHEDRON LETTERS, 1998, 39 (19) :2883-2886

[14]

KINGSTON DGI, 1993, PROG CHEM ORG NAT PR, V61, P1

[15] CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF C-2 TAXOIDS [J].

NICOLAOU, KC ;

RENAUD, J ;

NANTERMET, PG ;

COULADOUROS, EA ;

GUY, RK ;

WRASIDLO, W .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (09) :2409-2420

[16] A HIGHLY EFFICIENT ROUTE TO TAXOTERE BY THE BETA-LACTAM SYNTHON METHOD [J].

OJIMA, I ;

SUN, CM ;

ZUCCO, M ;

PARK, YH ;

DUCLOS, O ;

KUDUK, S .

TETRAHEDRON LETTERS, 1993, 34 (26) :4149-4152

[17]

PULICANI JP, 1994, TETRAHEDRON LETT, V32, P9717

[18]

VALDE DGV, 1993, J AM CHEM SOC, V115, P11650

[19] PLANT ANTITUMOR AGENTS .6. ISOLATION AND STRUCTURE OF TAXOL, A NOVEL ANTILEUKEMIC AND ANTITUMOR AGENT FROM TAXUS-BREVIFOLIA [J].

WANI, MC ;

TAYLOR, HL ;

WALL, ME ;

COGGON, P ;

MCPHAIL, AT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (09) :2325-&

[20] Skeletal rearrangement of A and B ring of 13-oxobaccatin III derivative [J].

Yu, CZ ;

Liu, ZY .

TETRAHEDRON LETTERS, 1997, 38 (23) :4133-4136

← 1 2 →