Acute myeloid leukaemia and the immune system: implications for immunotherapy

被引：32

作者：

Barrett, A. John ^{[1
]}

机构：

[1] George Washington Univ Hosp, GW Canc Ctr, 2150 Penn Ave NW, Washington, DC 20011 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 188卷 / 01期

关键词：

acute myeloid leukaemia; immune system; immunotherapy; NATURAL-KILLER-CELLS; NK CELLS; MYELOGENOUS LEUKEMIA; SUPPRESSOR-CELLS; DENDRITIC CELLS; AML CELLS; RESPONSES; THERAPY; TRIAL; CAR;

D O I：

10.1111/bjh.16310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recognition of the curative potential of the graft-versus-leukaemia effect for patients with acute myeloid leukaemia (AML) undergoing stem cell transplantation, and the emergence of immunotherapy as a powerful weapon to treat cancer, has spurred the exploration of the immune landscape of AML to apply immunotherapeutic approaches to curing the disease. While current concepts of cancer immunology and immunotherapy have relevance, there are also unique aspects of immune dysregulation in AML to be considered when designing rational immunotherapy for this leukaemia. This is timely because rapid advances in cancer immunobiology, together with technological developments have opened up the field of immunotherapy for malignant disease. Here the current knowledge of AML immunobiology is summarized together with a description of new immunotherapies to counter immunosuppression and immune evasion by AML. Recent advances in treatment with recombinant antibodies, adoptive cell therapy and vaccines and their future promise in AML treatment are reviewed.

引用

页码：147 / 158

页数：12

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