The Effect of Transarterial Y-90 Microsphere Treatment on Biochemical Parameters in Liver Tumors

Introduction: The aim of this study was to evaluate the effect of yttrium-90 (Y-90) microsphere transarterial radioembolization (TARE) treatment on early and late biochemical parameters and to determine the appropriate and effective follow-up schedule in the patients and to determine the biochemical parameters to be considered. Methods: A total of 106 patients with histopathologically verified primary or metastatic unresectable liver tumors that were treated with TARE at a single institution between 2016-2018 were retrospectively scanned from database. Of these patients, 27 patients (18 male and 9 female patients; mean age: 61.5 +/- 10.5 years, range: 40-77 years) were included in the study. It was investigated whether there was a significant difference between the biochemical parameters just before the treatment, on the 10th day and 3 months after the treatment. Results: Statistically significant difference was observed only between pre-treatment albumin (albumin 1) and 10th day albumin (albumin 2), and between pre-treatment albumin (albumin 1) and 3rd month albumin (albumin 3) levels (p<0.05). There was no statistically significant difference between other biochemical parameters (p>0.05). Conclusion: Albumin value was the most sensitive biochemical parameter in TARE treatment with Y-90 microsphere. It is of great importance that albumin value is frequently followed carefully in these patients.