Measurement of chemical shifts and coupling constants for glutamate and glutamine

被引：21

作者：

Govindaraju, V

Basus, VJ

Matson, GB

Maudsley, AA

机构：

[1] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Vet Affairs Med Ctr, MRS Unit, San Francisco, CA 94121 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1998年 / 39卷 / 06期

关键词：

glutamate; glutamine; J coupling; chemical shifts;

D O I：

10.1002/mrm.1910390620

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Proton chemical shifts and coupling constants were obtained for glutamate and glutamine in water (D2O) at pH = 6.6. Initial chemical shift and coupling constant values obtained from experimental spectra were refined using a spectral simulation and optimization program to get a complete set of values that could not otherwise be measured directly from the experimental spectra due to strong spin-spin couplings. These values are essential for automated spectral fitting procedures that require a priori information.

引用

页码：1011 / 1013

页数：3

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