Common polymorphisms of calpain-10 and the risk of Type 2 Diabetes in a Tunisian Arab population: a case-control study

被引:23
作者
Ezzidi, Intissar [1 ]
Turki, Amira [1 ]
Messaoudi, Safia [1 ]
Chaieb, Molka
Kacem, Maha [3 ]
Al-Khateeb, Ghada M. [4 ]
Mahjoub, Touhami [1 ]
Almawi, Wassim Y. [4 ]
Mtiraoui, Nabil [1 ,2 ]
机构
[1] Univ Monastir, Res Unit Biol & Genet Hematol & Autoimmune Dis, Fac Pharm Monastir, Monastir, Tunisia
[2] Univ Monastir, Higher Inst Biotechnol Monastir, Monastir, Tunisia
[3] CHU Fatouma Bourguiba, Nephrol & Internal Med Serv, Monastir, Tunisia
[4] Arabian Gulf Univ, Dept Med Biochem, Manama, Bahrain
关键词
INSULIN-RESISTANCE; GENETIC-VARIATION; CAPN10; GENE; ASSOCIATION; VARIANTS; SUSCEPTIBILITY; MELLITUS; CAUCASIANS; LINKAGE; LOCUS;
D O I
10.1186/1471-2350-11-75
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Genetic variations in the calpain-10 gene (CAPN10), in particular the at-risk diplotype (112/121), were previously implicated with increased risk of type 2 diabetes (T2D). Methods: We examined the association of CAPN10 UCSNP-43 (rs3792267), UCSNP-19 (rs3842570), and UCSNP-63 (rs5030952) SNPs with T2D in 917 Tunisian T2D patients and 748 non-diabetic controls. CAPN10 genotyping was done by PCR-RFLP. Results: Enrichment of UCSNP-19 2R (minor) allele and 2R/2R genotype was found in T2D patients; the allele and genotype distribution of UCSNP-43 and UCSNP-63 alleles and genotypes were not significantly different between patient groups and non-diabetic control subjects. Regression analysis demonstrated progressive increases in T2D risk in 3R/2R [OR (95% CI) = 1.35 (1.08 - 1.68)] and 2R/2R [OR (95% CI) = 1.61 (1.20 - 2.18)] genotypes. Of the six haplotypes detected, enrichment of haplotype 111 (UCSNP-43/UCSNP-19/UCSNP-63) was seen in patients (Pc = 0.034); the distribution of the other haplotypes was comparable between patients and control subjects; neither haplotype 211 nor haplotype 212 was observed. Furthermore, the frequency of all CAPN10 diplotypes identified, including the "high-risk diplotype (112/121) reported for Mexican-Americans and Northern Europeans, were comparable between patients and controls. Conclusions: CAPN10 UCSNP-19 variant, and the 111 haplotype contribute to the risk of T2D in Tunisian subjects; no significant associations between CAPN10 diplotypes and T2D were demonstrated for Tunisians.
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