Astrocytic D-amino acid oxidase degrades D-serine in the hindbrain

被引：11

作者：

Gonda, Yusuke ^{[1
,2
]}

Ishii, Chiharu ^{[3
]}

Mita, Masashi ^{[4
]}

Nishizaki, Naoto ^{[5
]}

Ohtomo, Yoshiyuki ^{[6
]}

Hamase, Kenji ^{[3
]}

Shimizu, Toshiaki ^{[2
]}

Sasabe, Jumpei ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Pharmacol, Tokyo 1608582, Japan

[2] Juntendo Univ, Grad Sch Med, Dept Pediat & Adolescent Med, Tokyo, Japan

[3] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka, Japan

[4] KAGAMI Inc, Ibaraki, Japan

[5] Juntendo Univ, Urayasu Hosp, Dept Pediat, Chiba, Japan

[6] Juntendo Univ, Nerima Hosp, Dept Pediat, Tokyo, Japan

来源：

FEBS LETTERS | 2022年 / 596卷 / 22期

关键词：

chirality; D-alanine; D-amino acid oxidase; D-serine; AMYOTROPHIC-LATERAL-SCLEROSIS; D-ALANINE; D-ASPARTATE; GLYCINE SITE; RAT-BRAIN; RACEMASE; MICE; NMDA; SCHIZOPHRENIA; LOCALIZATION;

D O I：

10.1002/1873-3468.14417

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

D-Serine modulates excitatory neurotransmission by binding to N-methyl-D-aspartate glutamate receptors. D-Amino acid oxidase (DAO) degrades D-amino acids, such as D-serine, in the central nervous system, and is associated with neurological and psychiatric disorders. However, cell types that express brain DAO remain controversial, and whether brain DAO influences systemic D-amino acids in addition to brain D-serine remains unclear. Here, we created astrocyte-specific DAO-conditional knockout mice. Knockout in glial fibrillary acidic protein-positive cells eliminated DAO expression in the hindbrain and increased D-serine levels significantly in the cerebellum. Brain DAO did not influence levels of D-amino acids in the forebrain or periphery. These results show that astrocytic DAO regulates D-serine specifically in the hindbrain.

引用

页码：2889 / 2897

页数：9

共 50 条

[1] ULTRASTRUCTURAL LOCALIZATION OF D-AMINO-ACID OXIDASE IN MICROPEROXISOMES OF THE RAT NERVOUS-SYSTEM [J].

ARNOLD, G ;

LISCUM, L ;

HOLTZMAN, E .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1979, 27 (03) :735-745

[2] Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior [J].

Basu, A. C. ;

Tsai, G. E. ;

Ma, C-L ;

Ehmsen, J. T. ;

Mustafa, A. K. ;

Han, L. ;

Jiang, Z. I. ;

Benneyworth, M. A. ;

Froimowitz, M. P. ;

Lange, N. ;

Snyder, S. H. ;

Bergeron, R. ;

Coyle, J. T. .

MOLECULAR PSYCHIATRY, 2009, 14 (07) :719-727

[3] A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia [J].

Bendikov, Inna ;

Nadri, Carmit ;

Amar, Shirly ;

Panizzutti, Rogerio ;

De Miranda, Joari ;

Wolosker, Herman ;

Agam, Galila .

SCHIZOPHRENIA RESEARCH, 2007, 90 (1-3) :41-51

[4] Cell Selective Conditional Null Mutations of Serine Racemase Demonstrate a Predominate Localization in Cortical Glutamatergic Neurons [J].

Benneyworth, Michael A. ;

Li, Yan ;

Basu, Alo C. ;

Bolshakov, Vadim Y. ;

Coyle, Joseph T. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2012, 32 (04) :613-624

[5] RENAL SERINE PRODUCTION INVIVO - EFFECTS OF DIETARY MANIPULATION OF SERINE STATUS [J].

BROSNAN, JT ;

HALL, B .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1989, 67 (09) :1058-1061

[6] D-amino acid oxidase activity and expression are increased in schizophrenia [J].

Burnet, P. W. J. ;

Eastwood, S. L. ;

Bristow, G. C. ;

Godlewska, B. R. ;

Sikka, P. ;

Walker, M. ;

Harrison, P. J. .

MOLECULAR PSYCHIATRY, 2008, 13 (07) :658-660

[7] Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia [J].

Chumakov, I ;

Blumenfeld, M ;

Guerassimenko, O ;

Cavarec, L ;

Palicio, M ;

Abderrahim, H ;

Bougueleret, L ;

Barry, C ;

Tanaka, H ;

La Rosa, P ;

Puech, A ;

Tahri, N ;

Cohen-Akenine, A ;

Delabrosse, S ;

Lissarrague, S ;

Picard, FP ;

Maurice, K ;

Essioux, L ;

Millasseau, P ;

Grel, P ;

Debailleul, V ;

Simon, AM ;

Caterina, D ;

Dufaure, I ;

Malekzadeh, K ;

Belova, M ;

Luan, JJ ;

Bouillot, M ;

Sambucy, JL ;

Primas, G ;

Saumier, M ;

Boubkiri, N ;

Martin-Saumier, S ;

Nasroune, M ;

Peixoto, H ;

Delaye, A ;

Pinchot, V ;

Bastucci, M ;

Guillou, S ;

Chevillon, M ;

Sainz-Fuertes, R ;

Meguenni, S ;

Aurich-Costa, J ;

Cherif, D ;

Gimalac, A ;

Van Duijn, C ;

Gauvreau, D ;

Quelette, G ;

Fortier, I ;

Realson, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13675-13680

[8] Evidence for NMDA and mGlu receptor-dependent long-term potentiation of mossy fiber-granule cell transmission in rat cerebellum [J].

D'Angelo, E ;

Rossi, P ;

Armano, S ;

Taglietti, V .

JOURNAL OF NEUROPHYSIOLOGY, 1999, 81 (01) :277-287

[9] Serine racemase modulates intracellular D-serine levels through an α,β-elimination activity [J].

Foltyn, VN ;

Bendikov, I ;

De Miranda, J ;

Panizzutti, R ;

Dumin, E ;

Shleper, M ;

Li, P ;

Toney, MD ;

Kartvelishvily, E ;

Wolosker, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (03) :1754-1763

[10] Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts [J].

Hamase, K ;

Konno, R ;

Morikawa, A ;

Zaitsu, K .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (09) :1578-1584

← 1 2 3 4 5 →