Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists

被引：28

作者：

Borza, I

Kolok, S

Gere, A

Agai-Csongor, É

Agai, B

Tárkányi, G

Horváth, C

Barta-Szalai, G

Bozó, É

Kiss, C

Bielik, A

Nagy, J

Farkas, S

Domány, G

机构：

[1] Gedeon Richter Chem Works Ltd, H-1475 Budapest, Hungary

[2] Budapest Univ Technol & Econ, H-1521 Budapest, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(03)00708-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3859 / 3861

页数：3

共 12 条

[1] OXIDATIVE COUPLING OF METHYL 6-HYDROXYINDOLE-2-CARBOXYLATE WITH PRIMARY AMINES - PREPARATION OF 2-SUBSTITUTED METHYL PYRROLO[2,3-E]BENZOXAZOLE-5-CARBOXYLATES [J].