Diversity across major and candidate genes in European local pig breeds

被引：70

作者：

Munoz, Maria ^{[1
]}

Bozzi, Riccardo ^{[2
]}

Garcia, Fabian ^{[1
]}

Nunez, Yolanda ^{[1
]}

Geraci, Claudia ^{[3
]}

Crovetti, Alessandro ^{[2
]}

Garcia-Casco, Juan ^{[1
]}

Alves, Estefania ^{[1
]}

Skrlep, Martin ^{[4
]}

Charneca, Rui ^{[5
]}

Martins, Jose M. ^{[5
]}

Quintanilla, Raquel ^{[6
]}

Tibau, Joan ^{[6
]}

Kusec, Goran ^{[7
]}

Djurkin-Kusec, Ivona ^{[7
]}

Mercat, Marie J. ^{[8
]}

Riquet, Juliette ^{[9
]}

Estelle, Jordi ^{[10
]}

Zimmer, Christoph ^{[11
]}

Razmaite, Violeta ^{[12
]}

Araujo, Jose P. ^{[13
]}

Radovic, Cedomir ^{[14
]}

Savic, Radomir ^{[15
]}

Karolyi, Danijel ^{[16
]}

Gallo, Maurizio ^{[17
]}

Candek-Potokar, Marjeta ^{[4
]}

Fontanesi, Luca ^{[3
]}

Fernandez, Ana, I ^{[1
]}

Ovilo, Cristina ^{[1
]}

机构：

[1] INIA, Dept Mejora Genet Anim, Madrid, Spain

[2] Univ Firenze, Florence, Italy

[3] Univ Bologna, Dept Agr & Food Sci, Bologna, Italy

[4] Agr Inst Slovenia, Ljubljana, Slovenia

[5] Univ Evora, ICAAM, Evora, Portugal

[6] IRTA, Programa Genet & Mejora Anim, Barcelona, Spain

[7] Univ Osijek, Fac Agrobiotech Sci, Osijek, Croatia

[8] IFIP, Inst Porc, Le Rheu, France

[9] INRA, Genet Physiol & Syst Elevage, Castanet Tolosan, France

[10] Univ Paris Saclay, AgroParisTech, INRA, GABI, Jouy En Josas, France

[11] Bauerl Erzeugergemeinschaft Schwabisch Hall, Schwabisch Hall, Germany

[12] Lithuanian Univ Hlth Sci, Anim Sci Inst, Baisogala, Lithuania

[13] Inst Politecn Viana do Castelo, Viana Do Castelo, Portugal

[14] Inst Anim Husb, Pig Res Dept, Belgrade, Serbia

[15] Univ Belgrade, Fac Agr, Belgrade, Serbia

[16] Univ Zagreb, Fac Agr, Dept Anim Sci, Zagreb, Croatia

[17] ANAS, Rome, Italy

来源：

PLOS ONE | 2018年 / 13卷 / 11期

基金：

欧盟地平线“2020”;

关键词：

MEAT QUALITY TRAITS; ESTROGEN-RECEPTOR LOCUS; FATTY-ACID-COMPOSITION; COAT COLOR; IGF2-INTRON3-G3072A SUBSTITUTION; BACKFAT THICKNESS; PROMOTER REGION; FEED-INTAKE; MC4R GENE; PORCINE;

D O I：

10.1371/journal.pone.0207475

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this work was to analyse the distribution of causal and candidate mutations associated to relevant productive traits in twenty local European pig breeds. Also, the potential of the SNP panel employed for elucidating the genetic structure and relationships among breeds was evaluated. Most relevant genes and mutations associated with pig morphological, productive, meat quality, reproductive and disease resistance traits were prioritized and analyzed in a maximum of 47 blood samples from each of the breeds (Alentejana, ApuloCalabrese, Basque, Bisara, Majorcan Black, Black Slavonian (Crna slavonska), Casertana, Cinta Senese, Gascon, Iberian, Kr6kopolje (Kr6kopoljski), Lithuanian indigenous wattle, Lithuanian White Old Type, Mora Romagnola, Moravka, Nero Siciliano, Sarda, Schwabisch-Hallisches Schwein (Swabian Hall pig), Swallow-Bellied Mangalitsa and Turopolje). We successfully analyzed allelic variation in 39 polymorphisms, located in 33 candidate genes. Results provide relevant information regarding genetic diversity and segregation of SNPs associated to production and quality traits. Coat color and morphological trait-genes that show low level of segregation, and fixed SNPs may be useful for traceability. On the other hand, we detected SNPs which may be useful for association studies as well as breeding programs. For instance, we observed predominance of alleles that might be unfavorable for disease resistance and boar taint in most breeds and segregation of many alleles involved in meat quality, fatness and growth traits. Overall, these findings provide a detailed catalogue of segregating candidate SNPs in 20 European local pig breeds that may be useful for traceability purposes, for association studies and for breeding schemes. Population genetic analyses based on these candidate genes are able to uncover some clues regarding the hidden genetic substructure of these populations, as the extreme genetic closeness between Iberian and Alentejana breeds and an uneven admixture of the breeds studied. The results are in agreement with available knowledge regarding breed history and management, although largest panels of neutral markers should be employed to get a deeper understanding of the population's structure and relationships.

引用

页数：30

共 123 条

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