The bioinformatics analysis of hepatitis C virus E2 protein

被引：0

作者：

Guo, Tailin ^{[1
]}

Wang, Shuhui ^{[1
]}

Wu, Yihong ^{[1
]}

机构：

[1] SW Jiaotong Univ, Sch Bioengn, Chengdu 610031, Peoples R China

来源：

PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON INTELLIGENT SYSTEMS AND KNOWLEDGE ENGINEERING (ISKE 2007) | 2007年

关键词：

hepatitis C virus; bioinformatics; E2; protein; epitopes; conservative sites;

D O I：

10.2991/iske.2007.131

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

By the methods of bioinformatics, the sequences of HCV E2 protein from all the genotypes are studied on the variation and the B-cell epitopes. We find that even in the HVR1 and HVR2 regions, there are also some conservative sites, such as T2, G6, G23, and Q26, all of which belong to polar R-base amino acids without charge, and can lost proton to conform hydrogen bond. Meanwhile, we find the conservative amino acids locate on the surface of E2 protein, make up of -turn and B-cell epitopes. This will contribute to prompt the development of HCV vaccine.

引用

页数：1

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