Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction

被引：46

作者：

Chen, Zhi ^{[1
]}

Chen, Long ^{[2
]}

Zeng, Chunyu ^{[1
]}

Wang, Wei Eric ^{[1
]}

机构：

[1] Third Mil Med Univ, Daping Hosp, Dept Cardiol, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China

[2] Soochow Univ, Coll Med, Suzhou 215123, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2018年 / 2018卷

基金：

中国国家自然科学基金;

关键词：

LEFT-VENTRICULAR FUNCTION; STROMAL CELLS; THERAPEUTIC-EFFICACY; CARDIAC-FUNCTION; DOUBLE-BLIND; TRANSENDOCARDIAL INJECTION; ISCHEMIC CARDIOMYOPATHY; ATTENUATES INFLAMMATION; INTRACORONARY INFUSION; PROGENITOR CELLS;

D O I：

10.1155/2018/7045245

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Myocardial infarction (MI) is one of the leading causes of death worldwide. Mesenchymal stem cell (MSC) transplantation is considered a promising approach and has made significant progress in preclinical studies and clinical trials for treating MI. However, hurdles including poor survival, retention, homing, and differentiation capacity largely limit the therapeutic effect of transplanted MSCs. Many strategies such as preconditioning, genetic modification, cotransplantation with bioactive factors, and tissue engineering were developed to improve the survival and function of MSCs. On the other hand, optimizing the hostile transplantation microenvironment of the host myocardium is also of importance. Here, we review the modifications of MSCs as well as the host myocardium to improve the efficacy of MSC-based therapy against MI.

引用

页数：14

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