Synthesis and antiviral activity of diverse heterocyclic scaffolds

被引:9
作者
Sharma, Shivali [1 ]
Utreja, Divya [1 ]
机构
[1] Punjab Agr Univ, Coll Basic Sci & Humanities, Dept Chem, Ludhiana 141004, Punjab, India
关键词
antiviral; heterocyclic; inhibitors; plant virus; structure-activity relationships; REVERSE-TRANSCRIPTASE INHIBITORS; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; IN-VITRO; DERIVATIVES; DESIGN; DISCOVERY; AGENTS; 1,2,3-TRIAZOLES; BINDING;
D O I
10.1111/cbdd.13953
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Heterocyclic moieties form a major part of organic chemistry as they are widely distributed in nature and have wide scale practical applications ranging from extensive clinical use to diverse fields such as medicine, agriculture, photochemistry, biocidal formulations, and polymer science. By virtue of their therapeutic properties, they could be employed in combating many infectious diseases. Among the common infectious diseases, viral infections are of great public health importance worldwide. Thus, there is an urgent need for the discovery and development of antiviral drugs and clinical methods to prevent various viral infections so as to increase the life expectancy. This review presents the comprehensive overview of the synthesis and antiviral activity of different heterocyclic compounds 2015 onwards, which aids in present knowledge and helps the researchers and other stakeholders to explore their field.
引用
收藏
页码:870 / 920
页数:51
相关论文
共 116 条
  • [1] Synthesis and Anti-influenza Virus Activity of Novel bis(4H-chromene-3-carbonitrile) Derivatives
    Abdella, Amna M.
    Moatasim, Yassmin
    Ali, Mohamed A.
    Elwahy, Ahmed H. M.
    Abdelhamid, Ismail A.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (03) : 1854 - 1862
  • [2] Pericyclic Reactions for Anti-HPV Antivirals: Unconventional Nucleoside Analogue Synthesis via Nitrosocarbonyl Chemistry
    Al-Saad, Dalya
    Memeo, Misal Giuseppe
    Quadrelli, Paolo
    [J]. CHEMISTRYSELECT, 2017, 2 (32): : 10340 - 10346
  • [3] Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication
    Ali, Akbar
    Wang, Jinhua
    Nathans, Robin S.
    Cao, Hong
    Sharova, Natalia
    Stevenson, Mario
    Rana, Tariq M.
    [J]. CHEMMEDCHEM, 2012, 7 (07) : 1217 - 1229
  • [4] Alkaloids from Cynanchum komarovii with inhibitory activity against the tobacco mosaic virus
    An, TY
    Huang, RQ
    Yang, Z
    Zhang, DK
    Li, GR
    Yao, YC
    Gao, J
    [J]. PHYTOCHEMISTRY, 2001, 58 (08) : 1267 - 1269
  • [5] Advances in Synthesis and Potentially Bioactive of Coumarin Derivatives
    Anamika
    Utreja, Divya
    Ekta
    Jain, Nisha
    Sharma, Shivali
    [J]. CURRENT ORGANIC CHEMISTRY, 2018, 22 (26) : 2509 - 2536
  • [6] Asymmetric synthesis and antiviral activity of novel chiral amino-pyrimidine derivatives
    Bai, Song
    Liu, Shan
    Zhu, Yunying
    Wu, Qin
    [J]. TETRAHEDRON LETTERS, 2018, 59 (33) : 3179 - 3183
  • [7] Synthesis and evaluation of novel hybrids β-carboline-4-thiazolidinones as potential antitumor and antiviral agents
    Barbosa, Valeria Aquilino
    Barea, Paula
    Mazia, Renata Sespede
    Ueda-Nakamura, Tania
    da Costa, Willian Ferreira
    Foglio, Mary Ann
    Goes Ruiz, Ana Lucia T.
    de Carvalho, Joao Ernesto
    Vendramini-Costa, Debora Barbosa
    Nakamura, Celso Vataru
    Sarragiotto, Maria Helena
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 124 : 1093 - 1104
  • [8] N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity
    Barbosa-Lima, Giselle
    da Silveira Pinto, Ligia S.
    Kaiser, Carlos R.
    Wardell, James L.
    De Freitas, Caroline S.
    Vieira, Yasmine R.
    Marttorelli, Andressa
    Neto, Jose Cerbino
    Bozza, Patricia T.
    Wardell, Solange M. S. V.
    de Souza, Marcus V. N.
    Souza, Thiago M. L.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 127 : 434 - 441
  • [9] Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV
    Bassetto, Marcella
    Leyssen, Pieter
    Neyts, Johan
    Yerukhimovich, Mark M.
    Frick, David N.
    Brancale, Andrea
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (04) : 936 - 940
  • [10] Computer-aided identification, design and synthesis of a novel series of compounds with selective antiviral activity against chikungunya virus
    Bassetto, Marcella
    De Burghgraeve, Tine
    Delang, Leen
    Massarotti, Alberto
    Coluccia, Antonio
    Zonta, Nicola
    Gatti, Valerio
    Colombano, Giampiero
    Sorba, Giovanni
    Silvestri, Romano
    Tron, Gian Cesare
    Neyts, Johan
    Leyssen, Pieter
    Brancale, Andrea
    [J]. ANTIVIRAL RESEARCH, 2013, 98 (01) : 12 - 18