Diethyl Chlorophosphate: A New Alternative Reagent for Dehydration of Primary Amides to Nitriles in Solvent and Solvent-Free Conditions

被引：4

作者：

Shahsavari-Fard, Z. ^{[1
]}

Sardarian, A. R. ^{[1
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Chem, Shiraz 71454, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2011年 / 8卷 / 01期

关键词：

Primary amides; Dehydration; Diethyl chlorophosphate; Nitriles; Solvent-free; EFFICIENT; CONVERSION; ALDOXIMES; SYSTEM; MILD;

D O I：

10.1007/BF03246217

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient method for synthesis of nitriles has been developed using diethyl chlorophosphate in solvent and solvent-free conditions. Primary alkyl and aryl amides, efficiently are converted to the corresponding nitriles by heating in the presence of diethyl chlorophosphate in excellent yields. This method works under mild conditions with shorter reaction times. [GRAPHICS] .

引用

页码：204 / 208

页数：5

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