A goblet cell carcinoma of the appendix presenting as an acute appendicitis: a case report

被引：0

作者：

Coevoet, D. ^{[1
]}

Maenhoudt, W. ^{[2
]}

Beaurang, J. ^{[2
]}

Bontinck, J. ^{[2
]}

Lockefeer, F. ^{[3
]}

Vandenabeele, L. ^{[4
]}

Rondou, T. ^{[4
]}

Bontinck, H. ^{[2
,5
]}

机构：

[1] Ghent Univ Hosp, Dept Med, Zonnestr 79, B-9160 Ghent, Belgium

[2] AZ Sint Jozef Hosp, Dept Gen Surg, Bornem, Belgium

[3] AZ Sint Jozef Hosp, Dept Pathol, Bornem, Belgium

[4] AZ Sint Jozef Hosp, Dept Gastroenterol, Bornem, Belgium

[5] Univ Hosp Ghent, Surg Unit, Ghent, Belgium

来源：

ACTA CHIRURGICA BELGICA | 2020年 / 120卷 / 02期

关键词：

Appendix vermiformis; goblet cell carcinoma; appendix tumours; NEUROENDOCRINE NEOPLASMS; MANAGEMENT; TUMORS; ILEUM;

D O I：

10.1080/00015458.2018.1500801

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: A goblet cell carcinoma of the appendix is a rare neoplasm with histological features of both adenocarcinomas and carcinoid tumours. It has a more aggressive behaviour in comparison to the more common classic neuroendocrine appendiceal tumours. Clinical presentation is variable and a significant proportion of patients present with an acute appendicitis. The aggressive evolution of these tumours makes the management more challenging. Case report: We report the case of a 43-year-old man with acute right iliac fossa pain who was initially diagnosed with an acute appendicitis. Histological analysis of the resected appendix demonstrated the presence of a goblet cell carcinoma with perineural and lymphovascular invasion. No distant metastasis was present. A right hemicolectomy was performed and adjuvant chemotherapy was administered. Conclusion: Goblet cell carcinomas is a distinct entity which should be delineated from the classical appendiceal carcinoids. Its clinical evolution obliges a more aggressive therapeutic strategy.

引用

页码：124 / 128

页数：5

共 15 条

[1] The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging [J].

Amin, Mahul B. ;

Greene, Frederick L. ;

Edge, Stephen B. ;

Compton, Carolyn C. ;

Gershenwald, Jeffrey E. ;

Brookland, Robert K. ;

Meyer, Laura ;

Gress, Donna M. ;

Byrd, David R. ;

Winchester, David P. .

CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (02) :93-99

[2] The NANETS Consensus Guideline for the Diagnosis and Management of Neuroendocrine Tumors Well-Differentiated Neuroendocrine Tumors of the Jejunum, Ileum, Appendix, and Cecum [J].

Boudreaux, J. Philip ;

Klimstra, David S. ;

Hassan, Manal M. ;

Woltering, Eugene A. ;

Jensen, Robert T. ;

Goldsmith, Stanley J. ;

Nutting, Charles ;

Bushnell, David L. ;

Caplin, Martyn E. ;

Yao, James C. .

PANCREAS, 2010, 39 (06) :753-766

[3] Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management [J].

Clift, Ashley K. ;

Kornasiewicz, Oskar ;

Drymousis, Panagiotis ;

Faiz, Omar ;

Wasan, Harpreet S. ;

Kinross, James M. ;

Cecil, Thomas ;

Frilling, Andrea .

ENDOCRINE CONNECTIONS, 2018, 7 (02) :268-277

[4]

GAGNE F, 1969, Annales d'Anatomie Pathologique, V14, P393

[5] Goblet Cell Carcinoids of the Appendix [J].

Holt, Nanna ;

Gronbaek, Henning .

SCIENTIFIC WORLD JOURNAL, 2013,

[6] Appendiceal Goblet Cell Carcinoids: Management Considerations from a Reference Peritoneal Tumour Service Centre and ENETS Centre of Excellence [J].

Lamarca, Angela ;

Nonaka, Daisuke ;

Escola, Cristina Lopez ;

Hubner, Richard A. ;

O'Dwyer, Sarah ;

Chakrabarty, Bipasha ;

Fulford, Paul ;

Valle, Juan W. .

NEUROENDOCRINOLOGY, 2016, 103 (05) :500-517

[7] Neuroendocrine Neoplasms of the Appendix: A Review of the Literature [J].

Moris, Dimitrios ;

Tsilimigras, Diamantis I. ;

Vagios, Stylianos ;

Ntanasis-Stathopoulos, Ioannis ;

Karachaliou, Georgia-Sofia ;

Papalampros, Alexandros ;

Alexandrou, Andreas ;

Blazer, Dan G., III ;

Felekouras, Evangelos .

ANTICANCER RESEARCH, 2018, 38 (02) :601-611

[8] Goblet cell carcinoid of the appendix [J].

Pahlavan P.S. ;

Kanthan R. .

World Journal of Surgical Oncology, 3 (1)

[9] ENETS Consensus Guidelines for the Management of Patients with Neuroendocrine Neoplasms from the Jejuno-Ileum and the Appendix Including Goblet Cell Carcinomas [J].

Pape, Ulrich-Frank ;

Perren, Aurel ;

Niederle, Bruno ;

Gross, David ;

Gress, Thomas ;

Costa, Frederico ;

Arnold, Rudolf ;

Denecke, Timm ;

Ploeckinger, Ursula ;

Salazar, Ramon ;

Grossman, Ashley .

NEUROENDOCRINOLOGY, 2012, 95 (02) :135-156

[10] Goblet cell carcinoid tumors of the appendix: An overview [J].

Roy, Paromita ;

Chetty, Runjan .

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2010, 2 (06) :251-258

← 1 2 →