Identification of Baicalin as an Immunoregulatory Compound by Controlling TH17 Cell Differentiation

被引：45
作者：
Yang, Ji [1 ]
Yang, Xue [2 ]
Chu, Yiwei [3 ]
Li, Ming [1 ]
机构：
[1] Fudan Univ, Dept Dermatol, Zhongshan Hosp, Shanghai 200433, Peoples R China
[2] Fudan Univ, Div Rheumatol, Huashan Hosp, Shanghai 200433, Peoples R China
[3] Fudan Univ, Dept Immunol, Shanghai Med Coll, Shanghai 200433, Peoples R China
来源：
PLOS ONE | 2011年 / 6卷 / 02期
基金：
中国国家自然科学基金;
关键词：
SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-HELPER-CELLS; ROR-GAMMA-T; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; ARYL-HYDROCARBON RECEPTOR; TH17; CELLS; TGF-BETA; ANTIINFLAMMATORY ACTIVITY; TISSUE INFLAMMATION; IL-23; RECEPTOR;
D O I：
10.1371/journal.pone.0017164
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
T(H)17 cells have been implicated in a growing list of inflammatory disorders. Antagonism of T(H)17 cells can be used for the treatment of inflammatory injury. Currently, very little is known about the natural compound controlling the differentiation of T(H)17 cells. Here, we showed that Baicalin, a compound isolated from a Chinese herb, inhibited T(H)17 cell differentiation both in vitro and in vivo. Baicalin might inhibit newly generated T(H)17 cells via reducing ROR gamma t expression, and together with up-regulating Foxp3 expression to suppress ROR gamma t-mediated IL-17 expression in established T(H)17 cells. In vivo treatment with Baicalin could inhibit T(H)17 cell differentiation, restrain T(H)17 cells infiltration into kidney, and protect MRL/lpr mice against nephritis. Our findings not only demonstrate that Baicalin could control T(H)17 cell differentiation but also suggest that Baicalin might be a promising therapeutic agent for the treatment of T(H)17 cells-mediated inflammatory diseases.
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页数：10
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