Prepulse inhibition and latent inhibition deficits in Roman high-avoidance vs. Roman low-avoidance rats: Modeling schizophrenia-related features

被引：24

作者：

Esnal, Aitor ^{[1
]}

Sanchez-Gonzalez, Ana ^{[1
]}

Rio-Alamos, Cristobal ^{[1
]}

Oliveras, Ignasi ^{[1
]}

Canete, Toni ^{[1
]}

Blazquez, Gloria ^{[1
]}

Tobena, Adolf ^{[1
]}

Fernandez-Teruel, Alberto ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Inst Neurosci, Dept Psychiat & Forens Med, Med Psychol Unit, E-08193 Barcelona, Spain

来源：

PHYSIOLOGY & BEHAVIOR | 2016年 / 163卷

关键词：

Schizophrenia-related symptoms; Roman high- and low-avoidance rats; Prepulse inhibition; Latent inhibition to a context; Latent inhibition to a cue; Fear-potentiated startle; FEAR-POTENTIATED STARTLE; BEHAVIORAL SENSITIZATION; STRESS RESPONSES; NOVELTY-SEEKING; STRAINS; LINES; ANXIETY; NEUROENDOCRINE; VULNERABILITY; EMOTIONALITY;

D O I：

10.1016/j.physbeh.2016.05.020

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The aim of the present study was to obtain further evidence supporting the validity of a new genetically-based rat model for the study of schizophrenia-relevant symptoms. The Roman high- (RHA-I) and low-avoidance (RLA-I) inbred rats have been psychogenetically selected for their rapid versus extremely poor acquisition of the two-way avoidance task in the shuttle box and present two well-differentiated profiles regarding several traits related to anxiety, impulsivity and sensitivity to (dopaminergic) psychostimulants. In this study we have tested animals from both strains in two behavioral paradigms that are related to schizophrenia, i.e. prepulse inhibition (PPI) and latent inhibition (LI) of fear-potentiated startle (FPS). The results show that while RLA-I rats display good PPI and LI to the context, RHA-Is show an impairment of PPI and no sign of an LI effect, which goes in the direction of the results obtained in schizophrenic patients. Therefore, although further behavioral and psychopharmacological work needs to be done, the present findings and previous studies carried out in our laboratory and others allow us to propose the RHA-I rat strain as a putative genetic rat model of differential schizophrenia-related features. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：267 / 273

页数：7

共 40 条

[1] Differences between two psychogenetically selected lines of rats in a swimming pool matching-to-place task:: Long-term effects of infantile stimulation [J].