Thin cylindrical diffusers in multimode Ge-doped silica fibers

被引:18
作者
Lilge, L
Vesselov, L
Whittington, W
机构
[1] Univ Hlth Network, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada
[3] Walsh Med Devices Inc, Oakville, ON L6L 5T7, Canada
关键词
photodynamic therapy; interstitial hyperthermia; oncology;
D O I
10.1002/lsm.20150
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background and Objectives: Cylindrical fiber diffusers are common tools in photodynamic therapy (PDT). However, large outer diameter and short length limit the indications to which they can be applied. Here a diffuser with an outer diameter of 250 pm and an active length exceeding 5 cm was developed. Study Design/Materials and Methods: Diffusers based on photosensitive quartz optical fibers with a cladding diameter of 140 pm were developed using a structured beam from an excimer laser. A complete set of photometric characteristics, including longitudinal, polar, and azimuth radiance emission diagrams were collected. Results and Conclusions: The longitudinal radiance emission is homogenous to within +/-10%. The ability to create custom designed longitudinal emission profiles was demonstrated. The variations of the polar and azimuth radiance emission diagrams were within +/-15% from an ideal Lambertian emitter. The polar uniformity can be improved with a slight increase of the outer diameter using a diffusing recoating compound. The residual light leakage at the distal end of the fiber diffuser was suppressed to 2%. The minimal bending radius after recoating is similar to 5 mm. Maximum power distribution is >0.5 W cm(-1).
引用
收藏
页码:245 / 251
页数:7
相关论文
共 31 条
[1]  
Bown S G, 2000, Gastrointest Endosc Clin N Am, V10, P533
[2]   Photodynamic therapy: Applications in atherosclerotic vascular disease with motexafin lutetium [J].
Chou, TM ;
Woodburn, KW ;
Cheong, WF ;
Lacy, SA ;
Sudhir, K ;
Adelman, DC ;
Wahr, D .
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 2002, 57 (03) :387-394
[3]   Monte Carlo simulation of light fluence in tissue in a cylindrical diffusing fibre geometry [J].
Farina, B ;
Saponaro, S ;
Pignoli, E ;
Tomatis, S ;
Marchesini, R .
PHYSICS IN MEDICINE AND BIOLOGY, 1999, 44 (01) :1-11
[4]  
Heisterkamp J, 1997, LASER SURG MED, V20, P304, DOI 10.1002/(SICI)1096-9101(1997)20:3<304::AID-LSM9>3.0.CO
[5]  
2-U
[6]   Effects of Pd-bacteriopheophorbide (TOOKAD)-mediated photodynamic therapy on canine prostate pretreated with ionizing radiation [J].
Huang, Z ;
Chen, Q ;
Trncic, N ;
LaRue, SM ;
Brun, PH ;
Wilson, BC ;
Shapiro, H ;
Hetzel, FW .
RADIATION RESEARCH, 2004, 161 (06) :723-731
[7]   Phase I drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment - Procedural and long-term results [J].
Kereiakes, DJ ;
Szyniszewski, AM ;
Wahr, D ;
Herrmann, HC ;
Simon, DI ;
Rogers, C ;
Kramer, P ;
Shear, W ;
Yeung, AC ;
Shunk, KA ;
Chou, TM ;
Popma, J ;
Fitzgerald, P ;
Carroll, TE ;
Forer, D ;
Adelman, DC .
CIRCULATION, 2003, 108 (11) :1310-1315
[8]   3-DIMENSIONAL CHARACTERIZATION OF THE LIGHT-DISTRIBUTION FROM DIFFUSING CYLINDRICAL OPTICAL-FIBER TIPS [J].
KOZODOY, RL ;
LUNDAHL, SL ;
BELL, D ;
HARRINGTON, JA .
APPLIED OPTICS, 1994, 33 (28) :6674-6682
[9]   Synthesis, comparative photosensitizing efficacy, human serum albumin (Site II) binding ability, and intracellular localization characteristics of novel benzobacteriochlorins derived from vic-dihydroxybacteriochlorins [J].
Li, GL ;
Graham, A ;
Chen, YH ;
Dobhal, MP ;
Morgan, J ;
Zheng, G ;
Kozyrev, A ;
Oseroff, A ;
Dougherty, TJ ;
Pandey, RK .
JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (25) :5349-5359
[10]   Coagulation and temperature distribution in Nd:YAG interstitial laser thermotherapy:: an in vitro animal study [J].
Lippert, BM ;
Teymoortash, A ;
Folz, BJ ;
Werner, JA .
LASERS IN MEDICAL SCIENCE, 2003, 18 (01) :19-24