Acute phosphate nephropathy secondary to the use of oral sodium phosphate laxatives. Report of one case

被引：0

作者：

Avila, Eduardo ^{[1
]}

Purto, Dalay ^{[5
]}

Kutscher, Sofia ^{[5
]}

Cornejo, Cristina ^{[5
]}

Severino, Nicolas ^{[2
,3
]}

Mendez, Gonzalo P. ^{[4
]}

Tagle, Rodrigo ^{[1
]}

机构：

[1] Pontificia Univ Catolica Chile, Fac Med, Dept Nefrol, Escuela Med, Santiago, Chile

[2] Pontificia Univ Catolica Chile, Fac Med, Escuela Med, Programa Farmacol & Toxicol, Santiago, Chile

[3] Pontificia Univ Catolica Chile, Fac Med, Dept Med Intens, Escuela Med, Santiago, Chile

[4] Pontificia Univ Catolica Chile, Fac Med, Dept Anat Patol, Escuela Med, Santiago, Chile

[5] Pontificia Univ Catolica Chile, Fac Med, Estudiante Escuela Med, Santiago, Chile

来源：

REVISTA MEDICA DE CHILE | 2021年 / 149卷 / 06期

关键词：

Acute Kidney Injury; Laxatives; RENAL-FUNCTION; BOWEL; COLONOSCOPY; FAILURE; RISK;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute phosphate nephropathy (APN) is an acute renal failure secondary to the use of oral sodium phosphate (OSP) laxatives, with a high risk of progression to chronicity. We report a 60-year-old woman with mixed connective tissue disease whose serum creatinine increased up to 2.0 mg/dL in her regular control tests, without an evident causative factor. Kidney biopsy showed numerous intratubular calcium phosphate deposits, consistent with APN. She had a history of OSP laxative intake, and a sodium phosphate enema was used before a colonoscopy performed six months earlier. The temporal association between the use of OSP laxatives and acute kidney injury, should lead to the suspicion of APN. The urine sediment is generally normal or with mild to moderate proteinuria. The diagnosis is confirmed with a kidney biopsy. Until now, there is no specific treatment for APN, thus prevention is essential. In high-risk patients for developing APN, the administration of these laxatives should be avoided.

引用

页码：934 / 938

页数：5