Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice

被引：14
作者：
Fujita, Chitose [1 ,2 ]
Sakurai, Yasuo [2 ,3 ]
Yasuda, Yuki [3 ]
Takada, Yoshikazu [4 ]
Huang, Cheng-Long [1 ,2 ]
Fujita, Masaaki [1 ,2 ,5 ,6 ]
机构：
[1] Kitano Hosp, Div Oncol, Tazuke Kofukai Med Res Inst, Osaka, Japan
[2] Japan Multinatl Trial Org, Nagoya, Aichi, Japan
[3] Canon Med Syst Corp, Otawara, Tochigi, Japan
[4] Univ Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA USA
[5] Kansai Elect Power Hosp, Div Clin Immunol & Rheumatol, Osaka, Japan
[6] Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Infect Dis, Osaka, Japan
来源：
JOURNAL OF IMMUNOLOGY | 2021年 / 207卷 / 07期
基金：
日本学术振兴会;
关键词：
BINDING; ALPHA-V-BETA-3; MECHANISMS; DARAPLADIB; ISOFORMS; DISEASE;
D O I：
10.4049/jimmunol.2100349
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 antimCRP mAb clones identified 3C as a clone recognizing the monomeric, but not polymeric, form of CRP. The anti-mCRP mAb suppressed leukocyte infiltration in thioglycollate-induced peritonitis, attenuated rheumatoid arthritis symptoms in collagen Ab-induced arthritis model mice, and attenuated lupus nephritis symptoms in MRL/Mp-lpr/lpr lupus-prone model mice. These data suggest that the anti-mCRP mAb 3C has therapeutic potential against rheumatoid arthritis and lupus nephritis.
引用
收藏
页码：1755 / 1762
页数：9
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