Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice

被引：16

作者：

Fujita, Chitose ^{[1
,2
]}

Sakurai, Yasuo ^{[2
,3
]}

Yasuda, Yuki ^{[3
]}

Takada, Yoshikazu ^{[4
]}

Huang, Cheng-Long ^{[1
,2
]}

Fujita, Masaaki ^{[1
,2
,5
,6
]}

机构：

[1] Kitano Hosp, Div Oncol, Tazuke Kofukai Med Res Inst, Osaka, Japan

[2] Japan Multinatl Trial Org, Nagoya, Aichi, Japan

[3] Canon Med Syst Corp, Otawara, Tochigi, Japan

[4] Univ Calif Davis, Sch Med, Dept Dermatol, Sacramento, CA USA

[5] Kansai Elect Power Hosp, Div Clin Immunol & Rheumatol, Osaka, Japan

[6] Kitano Hosp, Tazuke Kofukai Med Res Inst, Dept Infect Dis, Osaka, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2021年 / 207卷 / 07期

基金：

日本学术振兴会;

关键词：

BINDING; ALPHA-V-BETA-3; MECHANISMS; DARAPLADIB; ISOFORMS; DISEASE;

D O I：

10.4049/jimmunol.2100349

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Conformation-specific Ags are ideal targets for mAb-based immunotherapy. Here, we demonstrate that the monomeric form of C-reactive protein (mCRP) is a specific therapeutic target for arthritis and nephritis in a murine model. Screening of >1800 antimCRP mAb clones identified 3C as a clone recognizing the monomeric, but not polymeric, form of CRP. The anti-mCRP mAb suppressed leukocyte infiltration in thioglycollate-induced peritonitis, attenuated rheumatoid arthritis symptoms in collagen Ab-induced arthritis model mice, and attenuated lupus nephritis symptoms in MRL/Mp-lpr/lpr lupus-prone model mice. These data suggest that the anti-mCRP mAb 3C has therapeutic potential against rheumatoid arthritis and lupus nephritis.

引用

页码：1755 / 1762

页数：9

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