Steroidal saponins from Asparagus acutifolius

被引：33
|
作者：
Sautour, Marc
Miyamoto, Tomofumi
Lacaille-Dubois, Marie-Aleth
机构：
[1] Univ Bourgogne, Fac Pharm, UMIB UPRES EA 3660, Lab Pharmacognosie, F-21079 Dijon, France
[2] Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan
来源：
PHYTOCHEMISTRY | 2007年 / 68卷 / 20期
关键词：
Asparagus acutifolius; liliaceae; steroidal saponins; antifungal activity;
D O I：
10.1016/j.phytochem.2007.02.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six new steroidal saponins (1-6) were isolated from the roots of A. acutifolius L., together with a known spirostanol glycoside (7). Their structures were elucidated mainly by extensive spectroscopic analysis (1D and 2D NMR, FABMS and HRESIMS). Compounds 4-7 demonstrated antifungal activity against the human pathogenic yeasts C. albicans, C. glabrata and C. tropicalis with MICs values between 12.5 and 100 mu g/ml. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2554 / 2562
页数：9
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