Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2

被引：23
作者：
Okitsu, Yoko
Takahashi, Shinichiro
Minegishi, Naoko
Kameoka, Junichi
Kaku, Mitsuo
Yamamoto, Masayuki
Sasaki, Takeshi
Harigae, Hideo
机构：
[1] Tohoku Univ, Grad Sch Med, Dept Hematol & Rheumatol, Aoba Ku, Sendai, Miyagi 9808574, Japan
[2] Kitasato Univ, Grad Sch Med, Sagamihara, Kanagawa 2288555, Japan
[3] Tohoku Univ, Grad Sch Med, Biomed Engn Res Org, Aoba Ku, Sendai, Miyagi 9808574, Japan
[4] Tohoku Univ, Grad Sch Med, Infect Control & Clin Lab, Aoba Ku, Sendai, Miyagi 9808574, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 364卷 / 02期
关键词：
GATA-2; adipocyte differentiation; bone marrow;
D O I：
10.1016/j.bbrc.2007.10.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
GATA-2 is a transcription factor expressed in stem and progenitor cells of various cell lineages. In this study, we examined the role of GATA-2 in the differentiation of adipocytes, which are the main components of the microenvironment for hematopoiesis. Suppression of GATA-2 in TBR343, a preadipocytic stromal cell line, resulted in the acceleration of adipocyte differentiation. Conversely, overexpression of GATA-2 induced the resistance of adipocyte differentiation. In addition, regulatory elements of the GATA-2 gene in TBR343 are the same as those in hematopoietic cells. These results suggest that GATA-2 maintains a hematopoietic microenvironment by regulating the differentiation of adipocytes. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：383 / 387
页数：5
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