Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth

被引：30

作者：

Chen, Diane ^{[1
,2
,3
,4
]}

Strang, John F. ^{[5
,6
,7
,8
,9
]}

Kolbuck, Victoria D. ^{[1
]}

Rosenthal, Stephen M. ^{[10
]}

Wallen, Kim ^{[11
]}

Waber, Deborah P. ^{[12
,13
]}

Steinberg, Laurence ^{[14
]}

Sisk, Cheryl L. ^{[15
]}

Ross, Judith ^{[16
,17
]}

Paus, Tomas ^{[18
,19
,20
]}

Mueller, Sven C. ^{[21
,22
]}

McCarthy, Margaret M. ^{[23
]}

Micevych, Paul E. ^{[24
]}

Martin, Carol L. ^{[25
]}

Kreukels, Baudewijntje P. C. ^{[26
,27
]}

Kenworthy, Lauren ^{[5
,6
,7
,8
,9
]}

Herting, Megan M. ^{[28
,29
]}

Herlitz, Agneta ^{[30
]}

Haraldsen, Ira R. J. Hebold ^{[31
]}

Dahl, Ronald ^{[32
]}

Crone, Eveline A. ^{[33
]}

Chelune, Gordon J. ^{[34
]}

Burke, Sarah M. ^{[33
]}

Berenbaum, Sheri A. ^{[35
,36
]}

Beltz, Adriene M. ^{[37
]}

Bakker, Julie ^{[38
]}

Eliot, Lise ^{[39
]}

Vilain, Eric ^{[40
,41
,42
]}

Wallace, Gregory L. ^{[43
]}

Nelson, Eric E. ^{[44
,45
]}

Garofalo, Robert ^{[1
,4
]}

机构：

[1] Ann & Robert H Lurie Childrens Hosp Chicago, Potocsnak Family Div Adolescent & Young Adult Med, 225 East Chicago Ave,Box 161B, Chicago, IL 60611 USA

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Pritzker Dept Psychiat & Behav Hlth, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA

[4] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA

[5] Childrens Natl Med Ctr, Div Neuropsychol, Washington, DC 20010 USA

[6] Childrens Natl Med Ctr, Ctr Neurosci, Childrens Res Inst, Washington, DC 20010 USA

[7] George Washington Univ, Sch Med, Dept Pediat, Washington, DC 20052 USA

[8] George Washington Univ, Sch Med, Dept Neurol, Washington, DC USA

[9] George Washington Univ, Dept Psychiat, Sch Med, Washington, DC USA

[10] Univ Calif San Francisco, Benioff Childrens Hosp, Div Endocrinol, San Francisco, CA 94143 USA

[11] Emory Univ, Dept Psychol, Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA

[12] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA

[13] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[14] Temple Univ, Dept Psychol, Philadelphia, PA 19122 USA

[15] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA

[16] Nemours duPont Hosp Children, Delaware, OH USA

[17] Thomas Jefferson Univ, Dept Pediat, Philadelphia, PA 19107 USA

[18] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada

[19] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[20] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[21] Univ Ghent, Dept Expt Clin & Hlth Psychol, Ghent, Belgium

[22] Univ Deusto, Dept Personal Psychol Assessment & Treatment, Bilbao, Spain

[23] Univ Maryland, Sch Med, Dept Pharmacol, Program Neurosci, Baltimore, MD 21201 USA

[24] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[25] Arizona State Univ, Sch Social & Family Dynam, Tempe, AZ USA

[26] Amsterdam UMC, Locat VUmc, Dept Med Psychol, Amsterdam, Netherlands

[27] Ctr Expertise Gender Dysphoria, Amsterdam, Netherlands

[28] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90007 USA

[29] Univ Southern Calif, Dept Pediat, Los Angeles, CA 90007 USA

[30] Karolinska Inst, Dept Clin Neurosci, Sect Psychol, Stockholm, Sweden

[31] Oslo Univ Hosp, Ctr Cognit Hlth Brain Dis, Oslo, Norway

[32] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA

[33] Leiden Univ, Brain & Dev Res Ctr, Dept Dev & Educ Psychol, Leiden, Netherlands

[34] Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA

[35] Penn State Univ, Dept Psychol, University Pk, PA 16802 USA

[36] Penn State Univ, Dept Pediat, University Pk, PA 16802 USA

[37] Univ Michigan, Dept Psychol, Ann Arbor, MI USA

[38] Univ Liege, GIGA Neurosci, Liege, Belgium

[39] Rosalind Franklin Univ Med & Sci, Dept Neurosci, Chicago, IL USA

[40] Childrens Natl Med Ctr, Ctr Genet Med Res, Washington, DC 20010 USA

[41] George Washington Univ, Dept Genom & Precis Med, Washington, DC USA

[42] CNRS, Epigenet Data & Polit, Paris, France

[43] George Washington Univ, Dept Speech Language & Hearing Sci, Washington, DC USA

[44] Nationwide Childrens Hosp, Ctr Biobehav Hlth, Res Inst, Columbus, OH USA

[45] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH 43210 USA

来源：

TRANSGENDER HEALTH | 2020年 / 5卷 / 04期

关键词：

expert consensus; Delphi; puberty blockers; GnRHa; transgender; adolescents; AUTISM SPECTRUM DISORDERS; GENDER IDENTITY DISORDER; ADOLESCENT BRAIN; MESSENGER-RNA; RISK-TAKING; CHILDREN; CHILDHOOD; HORMONES; PERIOD; AGE;

D O I：

10.1089/trgh.2020.0006

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment. Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter. Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning. Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth.

引用

页码：246 / 257

页数：12

共 70 条

[41] Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex?
Piekarski, David J.
Johnson, Carolyn M.
Boivin, Josiah R.
Thomas, A. Wren
Lin, Wan Chen
Delevich, Kristen
Galarce, Ezequiel M.
Wilbrecht, Linda
[J]. BRAIN RESEARCH, 2017, 1654 : 123 - 144
[42] Longitudinal Examination of Adaptive Behavior in Autism Spectrum Disorders: Influence of Executive Function
Pugliese, Cara E.
Anthony, Laura Gutermuth
Strang, John F.
Dudley, Katerina
Wallace, Gregory L.
Naiman, Daniel Q.
Kenworthy, Lauren
[J]. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2016, 46 (02) : 467 - 477
[43] Late effects of pediatric brain tumors
Rey-Casserly, Celiane
Diver, Tanya
[J]. CURRENT OPINION IN PEDIATRICS, 2019, 31 (06) : 789 - 796
[44] The Delphi technique as a forecasting tool: issues and analysis
Rowe, G
Wright, G
[J]. INTERNATIONAL JOURNAL OF FORECASTING, 1999, 15 (04) : 353 - 375
[45] The Endocrinologist's Office-Puberty Suppression: Saving Children from a Natural Disaster?
Sadjadi, Sahar
[J]. JOURNAL OF MEDICAL HUMANITIES, 2013, 34 (02) : 255 - 260
[46] The amygdala: An agent of change in adolescent neural networks
Scherf, K. Suzanne
Smyth, Joshua M.
Delgado, Mauricio R.
[J]. HORMONES AND BEHAVIOR, 2013, 64 (02) : 298 - 313
[47] Brain Maturation, Cognition and Voice Pattern in a Gender Dysphoria Case under Pubertal Suppression
Schneider, Maiko A.
Spritzer, Poli M.
Borba Soll, Bianca Machado
Fontanari, Anna M. V.
Carneiro, Marina
Tovar-Moll, Fernanda
Costa, Angelo B.
da Silva, Dhiordan C.
Schwarz, Karine
Anes, Mauricio
Tramontina, Silza
Lobato, Maria I. R.
[J]. FRONTIERS IN HUMAN NEUROSCIENCE, 2017, 11
[48] Pubertal hormones, the adolescent brain, and the maturation of social behaviors: Lessons from the Syrian hamster
Schulz, Kalynn M.
Sisk, Cheryl L.
[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2006, 254 : 120 - 126
[49] The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development
Schulz, Kalynn M.
Sisk, Cheryl L.
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2016, 70 : 148 - 158
[50] A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D.
[J]. TRANSLATIONAL PSYCHIATRY, 2013, 3 : e238 - e238

← 1 2 3 4 5 6 7 →