Association between osteoarthritis-related serum biochemical markers over 11 years and knee MRI-based imaging biomarkers in middle-aged adults

被引:12
作者
Singh, A. [1 ]
Venn, A. [1 ]
Blizzard, L. [1 ]
Jones, G. [1 ]
Burgess, J. [1 ,2 ]
Parameswaran, V [1 ,2 ]
Cicuttini, F. [3 ]
March, L. [4 ,5 ,6 ]
Eckstein, F. [7 ,8 ,9 ]
Wirth, W. [7 ,8 ,9 ]
Ding, C. [1 ,3 ,10 ]
Antony, B. [1 ]
机构
[1] Univ Tasmania, Menzies Inst Med Res, Private Bag 23, Hobart, Tas 7000, Australia
[2] Royal Hobart Hosp, Dept Endocrinol, Hobart, Tas, Australia
[3] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia
[4] Univ Sydney, Inst Bone & Joint Res, Kolling Inst Med Res, Sydney, NSW, Australia
[5] Univ Sydney, Florance & Cope Professorial Rheumatol Dept, Sydney, NSW, Australia
[6] Royal North Shore Hosp, Sydney, NSW, Australia
[7] Chondrometr GmbH, Ainring, Germany
[8] Paracelsus Med Univ Salzburg & Nuremberg, Inst Anat & Cell Biol, Dept Imaging & Funct Musculoskeletal Res, Salzburg, Austria
[9] Paracelsus Med Univ, Ludwig Boltzmann Inst Arthrit & Rehabil, Salzburg, Austria
[10] Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, Guangzhou, Peoples R China
基金
英国医学研究理事会;
关键词
Osteoarthritis; Biomarkers; Magnetic resonance imaging (MRI); Cartilage degradation; Metalloproteinase; MATRIX PROTEIN COMP; CARTILAGE; PROGRESSION; HEALTH; CHILDHOOD; FOUNDATION; OVERWEIGHT; BONE;
D O I
10.1016/j.joca.2022.02.616
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Objective: To describe the associations between osteoarthritis (OA)-related biochemical markers (COMP, MMP-3, HA) and MRI-based imaging biomarkers in middle-aged adults over 10-13 years. Methods: Blood serum samples collected during the Childhood Determinants of Adult Health (CDAH)-1 study (year:2004-06; n = 156) and 10-13 year follow-up at CDAH-3 (n = 167) were analysed for COMP, MMP-3, and HA using non-isotopic ELISA. Knee MRI scans obtained during the CDAH-knee study (year:2008-10; n = 313) were assessed for cartilage volume and thickness, subchondral bone area, cartilage defects, and BML. Results: In a multivariable linear regression model describing the association of baseline biochemical markers with MRI-markers (assessed after 4-years), we found a significant negative association of standardised COMP with medial femorotibial compartment cartilage thickness (beta:-0.070; 95%CI:-0.138,-0.001), and standardised MMP-3 with patellar cartilage volume (beta:-141.548; 95%CI:-254.917,-28.179) and total bone area (beta:-0.729; 95%CI:-1.340,-0.118). In multivariable Tobit regression model, there was a significant association of MRI-markers with biochemical markers (assessed after 6-9 years); a significant negative association of patellar cartilage volume (beta:-0.001; 95%CI:-0.002,-0.00004), and total bone area (beta:-0.158; 95%CI-0.307,-0.010) with MMP-3, and total cartilage volume (beta:-0.001; 95%CI:-0.001,-0.0001) and total bone area (beta:-0.373; 95%CI:-0.636,-0.111) with COMP. No significant associations were observed between MRI-based imaging biomarkers and HA. Conclusion: COMP and MMP-3 levels were negatively associated with knee cartilage thickness and volume assessed 4-years later, respectively. Knee cartilage volume and bone area were negatively associated with COMP and MMP-3 levels assessed 6-9 years later. These results suggest that OA-related biochemical markers and MRI-markers are interrelated in early OA. (C) 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:756 / 764
页数:9
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