Synthesis of Deuterated (E)-Alkene through Xanthate-Mediated Hydrogen-Deuterium Exchange Reactions

被引：14

作者：

Li, Jiaming ^{[1
]}

Li, Jian ^{[1
]}

Ji, Xiaoliang ^{[1
]}

He, Runfa ^{[1
]}

Liu, Yang ^{[1
]}

Chen, Zebin ^{[1
]}

Huang, Yubing ^{[1
]}

Liu, Qiang ^{[1
,2
]}

Li, Yibiao ^{[1
]}

机构：

[1] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529090, Guangdong, Peoples R China

[2] Tsinghua Univ, Ctr Basic Mol Sci, Dept Chem, Beijing 100084, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 19期

关键词：

H/D EXCHANGE; PHARMACOKINETICS; SAFETY;

D O I：

10.1021/acs.orglett.1c02600

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we have developed a reversible hydrogen-deuterium exchange reaction of nonactivated olefins. By using EtOCS2K as a mediator, the H/D exchange reaction was realized through repeated addition and elimination reactions, demonstrating reversible H/D exchange between ordinary olefins and deuterated olefins. Using the lowest cost D2O without precious metal catalysts and ligands, a broad spectrum of compatibility of functional groups was achieved.

引用

页码：7412 / 7417

页数：6

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