Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke

被引:76
作者
Bennion, Douglas M. [1 ,2 ]
Haltigan, Emily [1 ,2 ]
Regenhardt, Robert W. [1 ,2 ]
Steckelings, U. Muscha [3 ]
Sumners, Colin [1 ,2 ]
机构
[1] Univ Florida, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA
[2] Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
[3] Univ Southern Denmark, Dept Cardiovasc & Renal Res, DK-5000 Odense C, Denmark
关键词
Angiotensin converting enzyme 2; Angiotensin-(1-7); Mas; Angiotensin type 1 receptor; Angiotensin type 2 receptor; Renin-angiotensin system; Stroke; Neuroprotection; Neuron; Microglia; Ischemia; Intracerebral hemorrhage; Inflammation; CONVERTING ENZYME 2; II TYPE-2 RECEPTOR; NITRIC-OXIDE SYNTHASE; SPONTANEOUSLY HYPERTENSIVE-RATS; IMPROVES ENDOTHELIAL FUNCTION; CEREBRAL-ARTERY OCCLUSION; RENIN-ANGIOTENSIN-SYSTEM; ISCHEMIC-STROKE; AT2; RECEPTOR; KAPPA-B;
D O I
10.1007/s11906-014-0512-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The discovery of beneficial neuroprotective effects of the angiotensin converting enzyme 2-angiotensin-(1-7)Mas axis [ACE2-Ang-(1-7)-Mas] in ischemic and hemorrhagic stroke has spurred interest in a more complete characterization of its mechanisms of action. Here, we summarize findings that describe the protective role of the ACE2Ang-(1-7)-Mas axis in stroke, along with a focused discussion on the potential mechanisms of neuroprotective effects of Ang-(1-7) in stroke. The latter incorporates evidence describing the actions of Ang-(1-7) to counter the deleterious effects of angiotensin II (AngII) via its type 1 receptor, including antiinflammatory, anti-oxidant, vasodilatory, and angiogenic effects, and the role of altered kinase-phosphatase signaling. Interactions of Mas with other receptors, including bradykinin receptors and AngII type 2 receptors are also considered. A more complete understanding of the mechanisms of action of Ang-(1-7) to elicit neuroprotection will serve as an essential step toward research into potential targeted therapeutics in the clinical setting.
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页数:10
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