A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

被引:17
作者
Karimi, Elham [1 ,2 ]
Arab, Arman [3 ]
Rafiee, Masoumeh [1 ]
Amani, Reza [1 ]
机构
[1] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Food Secur Res Ctr, Esfahan, Iran
[2] Univ Tehran Med Sci, Arash Womens Hosp, Res Dev Ctr, Tehran, Iran
[3] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran
关键词
ANTI-MULLERIAN HORMONE; INFERTILE WOMEN; D DEFICIENCY; 25-HYDROXYVITAMIN D; RISK-FACTORS; MARKERS; MEN; STEROIDOGENESIS; PREVALENCE; FERTILITY;
D O I
10.1038/s41598-021-95481-x
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD - 0.65; 95% CI - 1.28 to - 0.01; P=0.04; I-2=0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P=0.031; I-2=9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher's Z: - 0.18; 95% CI - 0.37 to - 0.008; P=0.041; I-2=51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.
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页数:18
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共 75 条
[1]   The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study [J].
Alavi, Nazanin ;
Ebrahimi, Mahbod ;
Akbari-Asbagh, Firoozeh .
INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE, 2020, 18 (02) :85-92
[2]   The association between serum vitamin D, fertility and semen quality: A systematic review and meta-analysis [J].
Arab, Arman ;
Hadi, Amir ;
Moosavian, Seyedeh Parisa ;
Askari, Gholamreza ;
Nasirian, Maryam .
INTERNATIONAL JOURNAL OF SURGERY, 2019, 71 :101-109
[3]   The Association Between Vitamin D and Premenstrual Syndrome: A Systematic Review and Meta-Analysis of Current Literature [J].
Arab, Arman ;
Golpour-Hamedani, Sahar ;
Rafie, Nahid .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2019, 38 (07) :648-656
[4]   Is the ovarian reserve influenced by vitamin D deficiency and the dress code in an infertile Iranian population? [J].
Arefi, Soheila ;
Khalili, Gholamreza ;
Iranmanesh, Homa ;
Farifteh, Fattaneh ;
Hosseini, Ahmad ;
Fatemi, Human M. ;
Lawrenz, Barbara .
JOURNAL OF OVARIAN RESEARCH, 2018, 11
[5]   Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women? [J].
Arslan, Emine ;
Gorkem, Umit ;
Togrul, Cihan .
GEBURTSHILFE UND FRAUENHEILKUNDE, 2019, 79 (07) :723-730
[6]   Association between vitamin D and dry eye disease: A systematic review and meta-analysis of observational studies [J].
Askari, Gholamreza ;
Rafie, Nahid ;
Miraghajani, Maryam ;
Heidari, Zahra ;
Arab, Arman .
CONTACT LENS & ANTERIOR EYE, 2020, 43 (05) :418-425
[7]   ANTI-MULLERIAN HORMONE AS A DIAGNOSTIC MARKER IN EGYPTIAN INFERTILE POLYCYSTIC OVARY SYNDROME FEMALES: CORRELATIONS WITH VITAMIN D, TOTAL TESTOSTERONE, DYSLIPIDEMIA AND ANTHROPOMETRIC PARAMETERS [J].
Bakeerl, Engy ;
Radwan, Rasha ;
El Mandoury, Ahmed ;
Abd El Rahman, Abdullah ;
Gad, Mohamed ;
Abd El Maksoud, Sahar .
JOURNAL OF MEDICAL BIOCHEMISTRY, 2018, 37 (04) :448-455
[8]   Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome [J].
Bakhshalizadeh, Shabnam ;
Amidi, Fardin ;
Alleyassin, Ashraf ;
Soleimani, Masoud ;
Shirazi, Reza ;
Nashtaei, Maryam Shabani .
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE, 2017, 63 (03) :150-161
[9]   Vitamin D and Anti-Mullerian Hormone Levels in Infertility Treatment: The Change-Point Problem [J].
Bednarska-Czerwinska, Anna ;
Olszak-Wasik, Katarzyna ;
Olejek, Anita ;
Czerwinski, Michal ;
Tukiendorf, Andrzej .
NUTRIENTS, 2019, 11 (05)
[10]   Vitamin D receptor rs2228570 polymorphism is associated with LH levels in men exposed to anabolic androgenic steroids [J].
Björkhem-Bergman L. ;
Lehtihet M. ;
Rane A. ;
Ekström L. .
BMC Research Notes, 11 (1)