Effect of chronic administration of ketamine on the mitochondrial respiratory chain activity caused by chronic mild stress

被引:10
|
作者
Rezin, Gislaine T. [1 ,3 ]
Goncalves, Cinara L. [1 ,3 ]
Daufenbach, Juliana F. [1 ,3 ]
Carvalho-Silva, Milena [1 ,3 ]
Borges, Lislaine S. [1 ,3 ]
Vieira, Julia S. [1 ,3 ]
Hermani, Fernanda V. [2 ,3 ]
Comim, Clarissa M. [2 ,3 ]
Quevedo, Joao [2 ,3 ]
Streck, Emilio L. [1 ,3 ]
机构
[1] Univ Extremo Catarinense, Programa Posgrad Ciencias Saude, Lab Fisiopatol Expt, Criciuma, SC, Brazil
[2] Univ Extremo Catarinense, Programa Posgrad Ciencias Saude, Lab Neurociencias, Criciuma, SC, Brazil
[3] Univ Extremo Catarinense, Inst Nacl Ciencia & Tecnol Translac Med, Criciuma, SC, Brazil
来源
ACTA NEUROPSYCHIATRICA | 2010年 / 22卷 / 06期
关键词
brain; chronic mild stress; ketamine; mitochondrial respiratory chain; MAJOR DEPRESSIVE DISORDER; ELECTRON-TRANSPORT CHAIN; CHRONIC VARIABLE STRESS; BRAIN MITOCHONDRIA; FEEDING-BEHAVIOR; NITRIC-OXIDE; RAT; DYSFUNCTION; ANTIDEPRESSANTS; PEROXYNITRITE;
D O I
10.1111/j.1601-5215.2010.00500.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Objective: Recently, we reported that mitochondrial respiratory chain complexes I, III and IV were inhibited in the cerebral cortex and cerebellum of rats submitted to chronic mild stress (CMS) and that acute ketamine administration reversed this effect. Therefore, we investigated whether the inhibition of these enzymes may be reversed by chronic administration of ketamine. Methods: Adult male Wistar rats were submitted to CMS and chronically treated with ketamine. After 40 days of CMS, consumption of sweet food, adrenal gland weight, body weight and enzymatic activity of the complexes were measured. Results: We verified that CMS decreased the intake of sweet food, increased the adrenal gland weight and the control group gained weight after 40 days but the stressed group did not; ketamine administration reversed these effects. We also verified that chronic administration of ketamine reversed the inhibition of complexes I, III and IV in cerebral cortex. However, in cerebellum, only complex IV inhibition was reversed. The chronic ketamine administration partially reverses the inhibition caused by CMS. Conclusion: We hypothesise that CMS inhibits complexes I, III and IV activities and that chronic administration of ketamine administration partially reverses such an effect. Therefore, it seems reasonable to propose that ketamine administration might be a useful therapy for patients affected by major depression.
引用
收藏
页码:292 / 299
页数:8
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