Omega-3 fatty acids are associated with blood-brain barrier integrity in a healthy aging population

被引:29
作者
Barnes, Samuel [1 ]
Chowdhury, Shilpy [1 ,2 ]
Gatto, Nicole M. [3 ]
Fraser, Gary E. [4 ]
Lee, Grace J. [5 ]
机构
[1] Loma Linda Univ, Med Ctr, Dept Radiol, Loma Linda, CA 92350 USA
[2] Loma Linda Univ, Sch Publ Hlth, Dept Nutr, Loma Linda, CA 92350 USA
[3] Claremont Grad Univ, Sch Community & Global Hlth, Claremont, CA USA
[4] Loma Linda Univ, Sch Publ Hlth, Ctr Nutr Hlth Lifestyle & Dis Prevent, Loma Linda, CA 92350 USA
[5] Loma Linda Univ, Sch Behav Hlth, Dept Psychol, Loma Linda, CA 92350 USA
关键词
blood-brain barrier; MRI; n-3; PUFA; neurocognitive tests; N-3; FATTY-ACIDS; HIGH-ENERGY DIET; ALZHEIMERS-DISEASE; OLDER-ADULTS; COGNITIVE PERFORMANCE; FISH CONSUMPTION; PERMEABILITY; RISK; VEGETARIAN; PATTERNS;
D O I
10.1002/brb3.2273
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In aging populations, omega-3 polyunsaturated fatty acids (PUFAs) have been associated with better cognitive function, slower rates of cognitive decline, and lower risk of developing dementia. Animal studies have shown that diets rich in omega-3 PUFAs reduce blood-brain barrier (BBB) disruption associated with aging, but this has yet to be observed in humans. Forty-five healthy subjects (mean age, 76 years) were recruited and underwent cognitive assessment (verbal learning and memory, language, processing speed, executive function, and motor control) and measurement of PUFAs. Forty of the same subjects also underwent magnetic resonance imaging (MRI) to measure BBB integrity (K-trans using dynamic contrast-enhanced MRI). The long chain omega-3 score (DHA+EPA) was negatively correlated with K-trans values in the internal capsule, indicating higher omega-3 levels were associated with greater BBB integrity in this region (r = -0.525, p = .004). Trends were observed for a positive correlation between the long chain omega-3 score and both memory and language scores, but not with executive function, speed, or motor control. The omega-6 score was not significantly correlated with any cognitive scores or K-trans values. The significant correlations between long chain omega-3 levels and BBB integrity provide a possible mechanism by which omega-3 PUFAs are associated with brain health.
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页数:10
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