Association between trace elements in cancerous and non-cancerous tissues with the risk of breast cancers in western Iran

被引:14
|
作者
Mansouri, Borhan [1 ]
Ramezani, Zana [2 ]
Yousefinejad, Vahid [3 ]
Nakhaee, Samaneh [4 ]
Azadi, Namamali [5 ]
Khaledi, Peyman [2 ]
Nikkhoo, Bahram [6 ]
Hassanzadeh, Kambiz [7 ]
Rahimi, Azin [6 ]
机构
[1] Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Hlth Inst, Kermanshah, Iran
[2] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran
[3] Kurdistan Univ Med Sci, Liver & Digest Res Ctr, Sanandaj, Iran
[4] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran
[5] Iran Univ Med Sci, Sch Publ Hlth, Biostat Dept, Tehran, Iran
[6] Kurdistan Univ Med Sci, Fac Med, Dept Pathol, Sanandaj, Iran
[7] Kurdistan Univ Med Sci, Cellular & Mol Res Ctr, Sanandaj, Iran
关键词
Breast cancer; Environmental exposure; Trace elements; Arsenic; Cadmium; HEAVY-METALS; HEALTH-RISKS; CADMIUM; BENIGN; TUMOR; MECHANISMS; TOXICITY; EXPOSURE; SELENIUM; BLOOD;
D O I
10.1007/s11356-021-16549-9
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
This study aimed to assess the tissue content of essential and toxic metals including lead (Pb), cadmium (Cd), arsenic (As), silver (Ag), aluminum (Al), chromium (Cr), copper (Cu), iron (Fe), selenium (Se), and zinc (Zn) in the breast cancerous tissues compared to the non-cancerous tissue. The biopsy specimens of 63 breast cancers along with 63 adjacent healthy tissues in Kurdistan Province, Iran, were collected from 2019 to 2020 and assayed using ICP-MS (Agilent 7900). The results of the Mann-Whitney test illustrated that the concentration of Pb, Cd, As, Cr, Cu, and Se were significantly elevated in cancerous tissue (p < 0.05), while Zn was the only trace element with higher levels in healthy subjects (p < 0.05). Moreover, weak to moderate correlations between elements were observed in the cancerous group including Al-Cr (r=0.60), As-Cu (r=0.52), and Cu-Se (r=0.56). In contrast, no correlation over 0.50 was found between trace elements in the non-cancerous group. Raw risk differences (RDs) accounted for a significant effect for Pb, Cd, As, Ag, Cr, Se, and Zn on the development of breast cancer. In conclusion, elevated levels of As, Cd, Cu, Pb, and Se may contribute to enhancing the risk of breast cancer.
引用
收藏
页码:11675 / 11684
页数:10
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