Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

被引：9
|
作者：
Ogawa, Tadashi [1 ]
Hattori, Hideki [1 ]
Kaneko, Rina [2 ]
Ito, Kenjiro [1 ]
Iwai, Masayo [1 ]
Mizutani, Yoko [1 ]
Arinobu, Tetsuya [3 ]
Ishii, Akira [2 ]
Suzuki, Osamu [4 ]
Seno, Hiroshi [1 ]
机构：
[1] Aichi Med Univ, Dept Legal Med, Sch Med, Aichi, 4801195, Japan
[2] Nagoya Univ, Dept Legal Med & Bioeth, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan
[3] Aichi Med Univ, Dept Chem, Med, Nagakute, Aichi 4801195, Japan
[4] Hamamatsu Univ Sch Med, Dept Legal Med, Hamamatsu, Shizuoka 4313192, Japan
来源：
ANALYTICAL SCIENCES | 2010年 / 26卷 / 10期
关键词：
AD-5423; SCHIZOPHRENIA; EFFICACY; HALOPERIDOL; METABOLITES;
D O I：
10.2116/analsci.26.1099
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented After pretreatment of a plasma sample by solid-phase extraction. blonanserin was analyzed by the system with a C(18) column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 001 - 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies
引用
收藏
页码：1099 / 1102
页数：4
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