Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives

被引：28

作者：

Pawar, Chandrakant D. ^{[1
]}

Sarkate, Aniket P. ^{[1
]}

Karnik, Kshipra S. ^{[1
]}

Bahekar, Sushilkumar S. ^{[2
]}

Pansare, Dattatraya N. ^{[1
]}

Shelke, Rohini N. ^{[3
]}

Jawale, Chetan S. ^{[4
]}

Shinde, Devanand B. ^{[5
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem Technol, Aurangabad 431004, Maharashtra, India

[2] Bond Life Sci Pvt Ltd, Aurangabad 431004, Maharashtra, India

[3] Deogiri Coll, Dept Chem, Stn Rd, Aurangabad 431005, Maharashtra, India

[4] HPT Arts & RYK Sci Coll, Coll Rd, Nasik 05, MS, India

[5] Shivaji Univ, Kolhapur 416004, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 15期

关键词：

Thiazole ring; Antibacterial activity; Antifungal activity; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITIES; FACILE SYNTHESIS; ANTIBACTERIAL; AGENTS; ANALOGS; THIAZOLES; ANTICONVULSANT; IDENTIFICATION; BENZOTRIAZOLE;

D O I：

10.1016/j.bmcl.2016.06.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel molecules containing thiazole ring structure were designed and synthesized. The structures of the synthesized compounds were elucidated and confirmed by H-1 NMR, C-13 NMR, Mass spectrum and the purity was checked through HPLC analysis. Among these synthesized compounds, 3a-3i and 6a-6c were tested for their antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity respectively. The results of the antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：3525 / 3528

页数：4

共 50 条

[41] Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents [J].

Kayhan Bolelli ;

Ismail Yalcin ;

Tugba Ertan-Bolelli ;

Selda Özgen ;

Fatma Kaynak-Onurdag ;

Ilkay Yildiz ;

Esin Aki .

Medicinal Chemistry Research, 2012, 21 :3818-3825

[42] Synthesis of novel 2-[4-(4-substitutedbenzamido/phenylacetamido)phenyl]benzothiazoles as antimicrobial agents [J].

Bolelli, Kayhan ;

Yalcin, Ismail ;

Ertan-Bolelli, Tugba ;

Ozgen, Selda ;

Kaynak-Onurdag, Fatma ;

Yildiz, Ilkay ;

Aki, Esin .

MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (11) :3818-3825

[43] Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents [J].

Neeraj Upmanyu ;

Sanjay Kumar ;

Pawan Porwal ;

Kamal Shah ;

Pradeep Mishra .

Medicinal Chemistry Research, 2012, 21 :1967-1976

[44] Synthesis and evaluation of 4-(substituted)-acetylamino-3-mercapto-5-(4-substituted) phenyl-1,2,4-triazole derivatives as antimicrobial agents [J].

Upmanyu, Neeraj ;

Kumar, Sanjay ;

Porwal, Pawan ;

Shah, Kamal ;

Mishra, Pradeep .

MEDICINAL CHEMISTRY RESEARCH, 2012, 21 (08) :1967-1976

[45] Synthesis and biological activity of 2-(3-carboxy phenyl)-5-(4-substituted phenyl)-1-acetyl-2-pyrazolines [J].

Havaldar, Freddy H. ;

Khatri, Navinchandra K. .

ASIAN JOURNAL OF CHEMISTRY, 2007, 19 (07) :5093-5097

[46] Synthesis and biological evaluation of 2-(4-substituted benzene-1-sulfonyl)-N'-(substituted-1-sulfonyl)acetohydrazide as antibacterial agents [J].

Li, Pei ;

Zhou, Junliang ;

Liu, Yan ;

Wang, Xiang .

CHEMICAL PAPERS, 2020, 74 (12) :4559-4565

[47] Synthesis and Antimicrobial Activities of Novel 2-[substituted-1H-pyrazol-4-yl] Benzothiazoles, Benzoxazoles, and Benzimidazoles [J].

Padalkar, Vikas S. ;

Borse, Bhushan N. ;

Gupta, Vinod D. ;

Phatangare, Kiran R. ;

Patil, Vikas S. ;

Sekar, Nagaian .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2016, 53 (05) :1347-1355

[48] Synthesis and evaluation of in vitro antimicrobial activity of novel 2-[2-(aroyl)aroyloxy]methyl-1,3,4-oxadiazoles [J].

Girish, V. ;

Khanum, Noor Fatima ;

Gurupadaswamy, H. D. ;

Khanum, Shaukath Ara .

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (03) :330-335

[49] Design, Synthesis and Activity Evaluation of 2-Ethyl-1-(4-substituted) Phenyl-1H- Imidazole Derivatives as Potent Antibacterial Agents [J].

Sun, Xian-Yu ;

Zhong, Chun-Yan ;

Liu, Mei-Yu ;

Qiu, Qing-Qing ;

Zheng, Gui-Lin ;

Lv, Ming-Yue ;

Pan, Chun-Yuan ;

Wang, Xin .

LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (04) :768-774

[50] Synthesis, spectroscopic, SC-XRD characterizations and DFT based studies of ethyl2-(substituted-(2-benzylidenehydrazinyl))thiazole-4-carboxylate derivatives [J].

Haroon, Muhammad ;

Khalid, Muhammad ;

Akhtar, Tashfeen ;

Tahir, Muhammad Nawaz ;

Khan, Muhammad Usman ;

Saleem, Muhammad ;

Jawaria, Rifat .

JOURNAL OF MOLECULAR STRUCTURE, 2019, 1187 :164-171

← 1 2 3 4 5 →