Proteinase-activated receptors (PARs) and immune function

被引：5
|
作者：
Fiorucci, S [1 ]
Distrutti, E [1 ]
机构：
[1] Univ Perugia, Dept Internal Med, Gastrointestinal Unit, I-06100 Perugia, Italy
来源：
DRUG DEVELOPMENT RESEARCH | 2003年 / 60卷 / 01期
关键词：
proteinases; PARs; thrombin; trypsin; tryptase; inflammation; lymphocytes; immune functions;
D O I：
10.1002/ddr.10322
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Proteinase-activated receptors (PARs) function as cell sensors for proteinases. Expression of PARs in immune cells suggests a role in innate immunity. PAR(1) mediates the cellular effects of thrombin and causes cytokine and chemokine production by endothelial cells and macrophages. Expression of PAR(1) on fibroblasts mediates the profibrogenic activity of thrombin and triggers extracellular matrix protein deposition. PAR(2) activation by trypsin, tryptase, and coagulation proteinases triggers both pro- and anti inflammatory activities by regulating monocyte recruitment/activation in inflamed tissues. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：65 / 70
页数：6
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