Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

被引：40

作者：

Frade, Amanda Farage ^{[1
,2
,5
,6
]}

Laugier, Laurie ^{[1
]}

Pinto Ferreira, Ludmila Rodrigues ^{[2
,5
,6
,7
]}

Baron, Monique Andrade ^{[2
,5
,6
]}

Benvenuti, Luiz Alberto ^{[3
]}

Teixeira, Priscila Camillo ^{[2
,5
,6
]}

Navarro, Isabela Cunha ^{[2
,5
,6
]}

Cabantous, Sandrine ^{[1
]}

Ferreira, Frederico Moraes ^{[2
,5
,6
,7
]}

Candido, Darlan da Silva ^{[2
,5
,6
]}

Gaiotto, Fabio Antonio ^{[3
]}

Bacal, Fernando ^{[4
]}

Pomerantzeff, Pablo ^{[4
]}

Barros Santos, Ronaldo Honorato ^{[3
]}

Kalil, Jorge ^{[1
,2
,5
]}

Cunha-Neto, Edecio ^{[2
,5
,6
]}

Chevillard, Christophe ^{[1
]}

机构：

[1] Aix Marseille Univ, INSERM, GIMP, UMR S906, F-13385 Marseille, France

[2] Univ Sao Paulo, Sch Med, Lab Immunol, Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Med, Div Pathol, Sao Paulo, Brazil

[4] Univ Sao Paulo, Sch Med, Inst Heart, Div Heart Transplantat, Sao Paulo, Brazil

[5] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo, Brazil

[6] Natl Inst Sci & Technol, Inst Invest Immunol, Sao Paulo, Brazil

[7] Univ Santo Amaro, Sao Paulo, Brazil

来源：

JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

dilated; cardiomyopathy; Chagas disease; lncRNA; MIAT; biomarker; MIAT; HEART; RISK;

D O I：

10.1093/infdis/jiw095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.

引用

页码：161 / 165

页数：5

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