Myocardial Infarction-Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

被引：42
作者：
Frade, Amanda Farage [1 ,2 ,5 ,6 ]
Laugier, Laurie [1 ]
Pinto Ferreira, Ludmila Rodrigues [2 ,5 ,6 ,7 ]
Baron, Monique Andrade [2 ,5 ,6 ]
Benvenuti, Luiz Alberto [3 ]
Teixeira, Priscila Camillo [2 ,5 ,6 ]
Navarro, Isabela Cunha [2 ,5 ,6 ]
Cabantous, Sandrine [1 ]
Ferreira, Frederico Moraes [2 ,5 ,6 ,7 ]
Candido, Darlan da Silva [2 ,5 ,6 ]
Gaiotto, Fabio Antonio [3 ]
Bacal, Fernando [4 ]
Pomerantzeff, Pablo [4 ]
Barros Santos, Ronaldo Honorato [3 ]
Kalil, Jorge [1 ,2 ,5 ]
Cunha-Neto, Edecio [2 ,5 ,6 ]
Chevillard, Christophe [1 ]
机构：
[1] Aix Marseille Univ, INSERM, GIMP, UMR S906, F-13385 Marseille, France
[2] Univ Sao Paulo, Sch Med, Lab Immunol, Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Med, Div Pathol, Sao Paulo, Brazil
[4] Univ Sao Paulo, Sch Med, Inst Heart, Div Heart Transplantat, Sao Paulo, Brazil
[5] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Sao Paulo, Brazil
[6] Natl Inst Sci & Technol, Inst Invest Immunol, Sao Paulo, Brazil
[7] Univ Santo Amaro, Sao Paulo, Brazil
来源：
JOURNAL OF INFECTIOUS DISEASES | 2016年 / 214卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
dilated; cardiomyopathy; Chagas disease; lncRNA; MIAT; biomarker; MIAT; HEART; RISK;
D O I：
10.1093/infdis/jiw095
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
引用
收藏
页码：161 / 165
页数：5
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