An intelligent sarco-endoplasmic reticulum Ca2+ store: Release and leak channels have differential access to a concealed Ca2+ pool

被引：44
|
作者：
Guerrero-Hernandez, Agustin [1 ]
Dagnino-Acosta, Adan [1 ]
Verkhratsky, Alexei [2 ]
机构：
[1] CINVESTAV, Dept Biochem, IPN, Mexico City 07000, DF, Mexico
[2] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England
来源：
CELL CALCIUM | 2010年 / 48卷 / 2-3期
关键词：
Endoplasmic reticulum; Ca2+ binding proteins; Ryanodine receptor; InsP(3) receptor; Ca2+ release; SMOOTH-MUSCLE-CELLS; SARCOPLASMIC-RETICULUM; CALCIUM-RELEASE; INTRACELLULAR STORES; CRYSTAL-STRUCTURE; SKELETAL-MUSCLE; CYTOSOLIC CA2+; CA-2+ RELEASE; SR CA2+; CALSEQUESTRIN;
D O I：
10.1016/j.ceca.2010.08.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Simultaneous recording of cytosolic and sarco-endoplasmic reticulum (SR/ER) luminal free calcium concentrations ([Ca2+](i) and [Ca2+](L,) respectively) supports the notion that release channels (RyRs and IP(3)Rs) use a concealed Ca2+ source, likely to be associated with intra-SR/ER Ca2+ binding proteins, whereas SR/ER Ca2+ leak channels can only access free luminal Ca2+. We hypothesize that Ca2+ is trapped by oligomers of luminal Ca2+-binding proteins and that the opening of release channels induces the rapid liberation of this "concealed" Ca2+ source associated with intra-ER Ca2+ buffers. Our hypothesis may also clarify why SERCA pumps potentiate Ca2+ release and explain quantal characteristics and refractory states of Ca2+ release process. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：143 / 149
页数：7
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