The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation

被引：59
作者：
Bush, Nicole R. [1 ,2 ]
Edgar, Rachel D. [3 ]
Park, Mina [4 ]
MacIsaac, Julia L. [3 ]
McEwen, Lisa M. [3 ]
Adler, Nancy E. [1 ]
Essex, Marilyn J. [5 ]
Kobor, Michael S. [3 ]
Boyce, W. Thomas [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Weill Neurosci Inst, Dept Psychiat, Ctr Hlth & Community, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA
[2] Univ Calif San Francisco, Div Dev Med, Dept Pediat, 550 16th St, San Francisco, CA 94158 USA
[3] Univ British Columbia, BC Childrens Hosp, Dept Med Genet, Ctr Mol Med & Therapeut, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada
[4] Univ British Columbia, Sch Populat & Publ Hlth, BC Childrens Hosp, 4480 Oak St, Vancouver, BC V6H 3N1, Canada
[5] Univ Wisconsin, Dept Psychiat, 16330 Ellendale Rd, Dallas, OR 97338 USA
来源：
EPIGENOMICS | 2018年 / 10卷 / 11期
关键词：
HEALTH; CHILDHOOD; EPIGENETICS; DISPARITIES; STRESS; TRAJECTORIES; ASSOCIATIONS; ENVIRONMENT; EXPRESSION; EXPERIENCE;
D O I：
10.2217/epi-2018-0042
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Aim: To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. Materials & methods: In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. Results: Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. Conclusion: Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.
引用
收藏
页码：1445 / 1461
页数：17
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