The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation

被引：59

作者：

Bush, Nicole R. ^{[1
,2
]}

Edgar, Rachel D. ^{[3
]}

Park, Mina ^{[4
]}

MacIsaac, Julia L. ^{[3
]}

McEwen, Lisa M. ^{[3
]}

Adler, Nancy E. ^{[1
]}

Essex, Marilyn J. ^{[5
]}

Kobor, Michael S. ^{[3
]}

Boyce, W. Thomas ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Weill Neurosci Inst, Dept Psychiat, Ctr Hlth & Community, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA

[2] Univ Calif San Francisco, Div Dev Med, Dept Pediat, 550 16th St, San Francisco, CA 94158 USA

[3] Univ British Columbia, BC Childrens Hosp, Dept Med Genet, Ctr Mol Med & Therapeut, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada

[4] Univ British Columbia, Sch Populat & Publ Hlth, BC Childrens Hosp, 4480 Oak St, Vancouver, BC V6H 3N1, Canada

[5] Univ Wisconsin, Dept Psychiat, 16330 Ellendale Rd, Dallas, OR 97338 USA

来源：

EPIGENOMICS | 2018年 / 10卷 / 11期

关键词：

HEALTH; CHILDHOOD; EPIGENETICS; DISPARITIES; STRESS; TRAJECTORIES; ASSOCIATIONS; ENVIRONMENT; EXPRESSION; EXPERIENCE;

D O I：

10.2217/epi-2018-0042

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. Materials & methods: In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. Results: Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. Conclusion: Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.

引用

页码：1445 / 1461

页数：17

共 67 条

[1] Rigor, vigor, and the study of health disparities [J].

Adler, Nancy ;

Bush, Nicole R. ;

Pantell, Matthew S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 :17154-17159

[2] Health disparities across the lifespan: Meaning, methods, and mechanisms [J].

Adler, Nancy E. ;

Stewart, Judith .

BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH, 2010, 1186 :5-+

[3] The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes [J].

Ai Ling Teh ;

Pan, Hong ;

Chen, Li ;

Ong, Mei-Lyn ;

Dogra, Shaillay ;

Wong, Johnny ;

MacIsaac, Julia L. ;

Mah, Sarah M. ;

McEwen, Lisa M. ;

Saw, Seang-Mei ;

Godfrey, Keith M. ;

Chong, Yap-Seng ;

Kwek, Kenneth ;

Kwoh, Chee-Keong ;

Soh, Shu-E. ;

Chong, Mary F. F. ;

Barton, Sheila ;

Karnani, Neerja ;

Cheong, Clara Y. ;

Buschdorf, Jan Paul ;

Stunkel, Walter ;

Kobor, Michael S. ;

Meaney, Michael J. ;

Gluckman, Peter D. ;

Holbrook, Joanna D. .

GENOME RESEARCH, 2014, 24 (07) :1064-1074

[4] Prenatal Adversities and Latino Children's Autonomic Nervous System Reactivity Trajectories from 6 Months to 5 Years of Age [J].

Alkon, Abbey ;

Boyce, W. Thomas ;

Linh Tran ;

Harley, Kim G. ;

Neuhaus, John ;

Eskenazi, Brenda .

PLOS ONE, 2014, 9 (01)

[5]

[Anonymous], DEV PSYCHOPATHOLOGY

[6]

[Anonymous], 2015, Nucl. Acids Res, V43, pD1049

[7] Fitting Linear Mixed-Effects Models Using lme4 [J].

Bates, Douglas ;

Maechler, Martin ;

Bolker, Benjamin M. ;

Walker, Steven C. .

JOURNAL OF STATISTICAL SOFTWARE, 2015, 67 (01) :1-48

[8] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[9] Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder [J].

Berko, Esther R. ;

Suzuki, Masako ;

Beren, Faygel ;

Lemetre, Christophe ;

Alaimo, Christine M. ;

Calder, R. Brent ;

Ballaban-Gil, Karen ;

Gounder, Batya ;

Kampf, Kaylee ;

Kirschen, Jill ;

Maqbool, Shahina B. ;

Momin, Zeineen ;

Reynolds, David M. ;

Russo, Natalie ;

Shulman, Lisa ;

Stasiek, Edyta ;

Tozour, Jessica ;

Valicenti-McDermott, Maria ;

Wang, Shenglong ;

Abrahams, Brett S. ;

Hargitai, Joseph ;

Inbar, Dov ;

Zhang, Zhengdong ;

Buxbaum, Joseph D. ;

Molholm, Sophie ;

Foxe, John J. ;

Marion, Robert W. ;

Auton, Adam ;

Greally, John M. .

PLOS GENETICS, 2014, 10 (05)

[10] Epigenome-wide Association Studies and the Interpretation of Disease -Omics [J].

Birney, Ewan ;

Smith, George Davey ;

Greally, John M. .

PLOS GENETICS, 2016, 12 (06)

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