Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles

被引：23
作者：
Alp, Ayse Selen [1 ]
Kilcigil, Gulgun [1 ]
Ozdamar, Elcin Deniz [2 ]
Coban, Tulay [2 ]
Eke, Binay [2 ]
机构：
[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey
[2] Ankara Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-06100 Ankara, Turkey
来源：
TURKISH JOURNAL OF CHEMISTRY | 2015年 / 39卷 / 01期
关键词：
Antioxidant; lipid peroxidation; benzimidazole; oxadiazole; imine; LIPID PEROXIDE FORMATION; BENZIMIDAZOLE; DERIVATIVES; ANTIFUNGAL;
D O I：
10.3906/kim-1403-44
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some novel 2-(substitutedbenzylthio)-5-((2- (4-substitutedpheny1)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles (5-12) and 2-(2-(4-chlorophenyl)-1H-benzo[d] imidazol-1-yl)-N'-(arylmethylene)acetohydrazide derivatives (13-22) were prepared and their in vitro antioxidant properties were investigated by determination of rat liver microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound 18 was found to be the most active compound with 100% inhibition on LP level and 92% inhibition on EROD. Compounds 4b, 17, and 19 showed the strongest inhibitory effect (97%) on EROD. The free radical scavenging capacities of the compounds were also tested in vitro determining the interaction of the stable free radical 2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and 4b exhibited good antioxidant activities.
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页码：42 / 53
页数：12
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