Synthesis and evaluation of antioxidant activities of novel 1,3,4-oxadiazole and imine containing 1H-benzimidazoles

被引：23

作者：

Alp, Ayse Selen ^{[1
]}

Kilcigil, Gulgun ^{[1
]}

Ozdamar, Elcin Deniz ^{[2
]}

Coban, Tulay ^{[2
]}

Eke, Binay ^{[2
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Ankara Univ, Fac Pharm, Dept Pharmaceut Toxicol, TR-06100 Ankara, Turkey

来源：

TURKISH JOURNAL OF CHEMISTRY | 2015年 / 39卷 / 01期

关键词：

Antioxidant; lipid peroxidation; benzimidazole; oxadiazole; imine; LIPID PEROXIDE FORMATION; BENZIMIDAZOLE; DERIVATIVES; ANTIFUNGAL;

D O I：

10.3906/kim-1403-44

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Some novel 2-(substitutedbenzylthio)-5-((2- (4-substitutedpheny1)-1H-benzo[d]imidazol-1-yl)methyl)-1,3,4-oxadiazoles (5-12) and 2-(2-(4-chlorophenyl)-1H-benzo[d] imidazol-1-yl)-N'-(arylmethylene)acetohydrazide derivatives (13-22) were prepared and their in vitro antioxidant properties were investigated by determination of rat liver microsomal NADPH-dependent inhibition of lipid peroxidation (LP) levels and microsomal ethoxyresorufin O-deethylase (EROD) activity. Compound 18 was found to be the most active compound with 100% inhibition on LP level and 92% inhibition on EROD. Compounds 4b, 17, and 19 showed the strongest inhibitory effect (97%) on EROD. The free radical scavenging capacities of the compounds were also tested in vitro determining the interaction of the stable free radical 2,2,diphenyl-1-picrylhydrazyl (DPPH), and compounds 4a and 4b exhibited good antioxidant activities.

引用

页码：42 / 53

页数：12

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