Update on Epidemiology, Diagnosis, and Disease Course of Atopic Dermatitis

被引：37
作者：
Simpson, Eric L. [1 ,2 ]
Irvine, Alan D. [3 ,4 ,5 ]
Eichenfield, Lawrence F. [6 ,7 ]
Friedlander, Sheila F. [8 ,9 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Dermatol, Dermatol, Portland, OR 97201 USA
[2] Oregon Hlth & Sci Univ, Dept Dermatol, Clin Studies, Portland, OR 97201 USA
[3] Trinity Coll Dublin, Dermatol, Crumlin, Ireland
[4] Our Ladys Childrens Hosp, Crumlin, Ireland
[5] St James Hosp, Dublin, Ireland
[6] Univ Calif San Diego, San Diego Sch Med, Rady Childrens Hosp, Dermatol & Pediat, San Diego, CA 92103 USA
[7] Univ Calif San Diego, San Diego Sch Med, Rady Childrens Hosp, Pediat & Adolescent Dermatol, San Diego, CA 92103 USA
[8] Univ Calif San Diego, San Diego Sch Med, Dermatol & Pediat, San Diego, CA 92103 USA
[9] Rady Childrens Hosp, Pediat & Adolescent Dermatol, San Diego, CA USA
来源：
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY | 2016年 / 35卷
关键词：
Atopic dermatitis; eczema; filaggrin; food allergy; peanut allergy; obesity; skin infection; FOOD ALLERGY; POTENTIAL ROLE; RISK-FACTORS; ECZEMA; CHILDHOOD; ASSOCIATION; PREVALENCE; EXPOSURE; ASTHMA; CHILDREN;
D O I：
10.12788/j.sder.2016.041
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Studies of the prevalence of atopic dermatitis (AD) have provided insights into associated environmental risk factors, demonstrating the complex interactions between the presence of filaggrin (FLG) gene defects and environment.Among other important findings is that elevated transepidermal water loss (TEWL) in newborns is a strong predictor of AD, regardless of FLG status. Recently recognized predictors of disease course and severity include onset of AD signs and symptoms before 12 months of age and the presence of an FLG mutation and concomitant immunoglobulin E sensitization early in life. (C) 2016 published by Frontline Medical Communications
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收藏
页码：S84 / S88
页数：5
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