D1 and D2 dopamine receptor mediation of amphetamine-induced acetylcholine release in nucleus accumbens

被引:26
作者
Keys, AS [1 ]
Mark, GP [1 ]
机构
[1] Oregon Hlth & Sci Univ, Sch Med, Dept Behav Neurosci, Portland, OR 97201 USA
关键词
microdialysis; SCH; 23390; sulpiride; reverse dialysis; psychostimulant; rat;
D O I
10.1016/S0306-4522(98)00018-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To assess the interaction of dopamine and acetylcholine systems in the rat nucleus accumbens in response to direct D-amphetamine administration, in vivo microdialysis measures of acetylcholine were used during reverse dialysis of amphetamine alone and in combination with D-1 and D-2 receptor antagonists SCH 23390 and sulpiride, respectively. During a 15-min exposure to amphetamine (50 mu M) in the nucleus accumbens, acetylcholine increased to 33% above pre-infusion levels, became maximal at 15 min post-infusion (+41%) and gradually returned to baseline levels by 60 min post-amphetamine. Conversely, amphetamine (1 mM) administration caused a biphasic change in acetylcholine release with a trend toward a decrease (-14%) during exposure followed by a significant increase (+36%) at 30 min post-amphetamine that returned to baseline levels by 60 min after infusion. The increases observed during amphetamine (50 mu M) exposure and during recovery from amphetamine (1 mM) were both blocked by co-administration with the D-1 antagonist, SCH 23393 (10 mu M), but not with the D-2 antagonist, sulpiride (10 mu M). Go-infusion of sulpiride eliminated the trend toward reduced acetylcholine release observed during 1 mM amphetamine whereas co-administration of SCH 23390 potentiated this decrease. A possible tonic D-1 facilitation of nucleus accumbens acetylcholine release was indicated by the consistent reductions in acetylcholine release observed during infusion of SCH 23390. These results suggest that amphetamine administration in the nucleus accumbens induces a bidirectional change in acetylcholine release that is dependent on dose and opposing effects of nucleus accumbens D-1 and D-2 activation. In general, relatively low doses of amphetamine administered into the nucleus accumbens caused an increase in acetylcholine release that was dependent on dopamine D-1 receptors whereas higher doses of amphetamine resulted in a D-2-mediated decrease. (C) 1998 IBRO. Published by Elsevier Science Ltd.
引用
收藏
页码:521 / 531
页数:11
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