Should We Assess Vitamin D Status in Pediatric Patients With Celiac Disease?

被引:15
作者
Ahlawat, Rajni [1 ]
Weinstein, Toba [1 ]
Markowitz, James [1 ]
Kohn, Nina [2 ]
Pettei, Michael J. [1 ]
机构
[1] Steven & Alexandra Cohen Childrens Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, New York, NY USA
[2] Feinstein Inst Med Res, Dept Biostat, New York, NY USA
关键词
25-hydroxyvitamin D; celiac disease; children; vitamin D; BONE-MINERAL DENSITY; 25-HYDROXYVITAMIN D LEVELS; D DEFICIENCY; CHILDREN; DIAGNOSIS; ADOLESCENTS; PREVALENCE; GUIDELINES; MANAGEMENT; SOCIETY;
D O I
10.1097/MPG.0000000000002417
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: Screening for vitamin D status in celiac disease (CD) has been recommended but the literature provides varying support. We sought to assess the vitamin D status in newly diagnosed children with CD and in a non-CD control population and relate them to vitamin D intake. Methods: In a cross-sectional study, serum 25-hydroxyvitamin D (25-OHD) levels were drawn in children with newly diagnosed CD and compared with pediatric outpatients with functional abdominal complaints. Anthropometric data as well as vitamin D intake based on milk and multivitamin ingestion were collected. Results: Thirty-eight newly diagnosed CD patients (10.4 +/- 3.0 years old; 50% girls) and 82 controls (11.2 +/- 4.2 years old; 58.5% girls) were studied. Both groups were similar except for average daily D intake and BMI. There was no statistical difference in mean 25-OHD levels between CD (26.4 +/- 8.0 ng/mL) and controls (23.5 +/- 8.2 ng/mL) [P <= 0.07]. Both groups had high percentages of suboptimal D status (65.8% CD and 79.3% controls). 25-OHD levels significantly correlated with age (r = -0.262; P < 0.0038) and estimated vitamin D intake (r = 0.361; P < 0.0001). Conclusions: No significant difference in 25-OHD levels was noted between newly diagnosed CD and controls, but inadequate 25-OHD levels were common in both. 25-OHD levels were highly associated with vitamin D intake demonstrating similar vitamin D absorption between patients and controls. As CD is associated with bone disease and D status is frequently low, efforts at optimizing D, such as screening levels at diagnosis need to be conducted.
引用
收藏
页码:449 / 454
页数:6
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