Mean upper cervical cord area (MUCCA) measurement in long-standing multiple sclerosis: Relation to brain findings and clinical disability

被引:71
作者
Daams, Marita [1 ]
Weiler, Florian [2 ]
Steenwijk, Martijn D. [1 ]
Hahn, Horst K. [2 ]
Geurts, Jeroen J. G. [1 ]
Vrenken, Hugo [1 ]
van Schijndel, Ronald A. [1 ]
Balk, Lisanne J. [1 ]
Tewarie, Prejaas K. [1 ]
Tillema, Jan-Mendelt [1 ,3 ]
Killestein, Joep [1 ]
Uitdehaag, Bernard M. J. [1 ]
Barkhof, Frederik [1 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, NL-1007 MB Amsterdam, Netherlands
[2] Inst Med Image Comp, Fraunhofer MEVIS, Bremen, Germany
[3] Mayo Clin, Rochester, MN USA
关键词
Multiple sclerosis; spinal cord; atrophy; magnetic resonance imaging; disability evaluation; SPINAL-CORD; ATROPHY; SEGMENTATION; MRI; VOLUME; GRAY;
D O I
10.1177/1352458514533399
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The majority of patients with multiple sclerosis (MS) present with spinal cord pathology. Spinal cord atrophy is thought to be a marker of disease severity, but in long-disease duration its relation to brain pathology and clinical disability is largely unknown. Objective: Our aim was to investigate mean upper cervical cord area (MUCCA) in patients with long-standing MS and assess its relation to brain magnetic resonance imaging (MRI) measures and clinical disability. Methods: MUCCA was measured in 196 MS patients and 55 healthy controls using 3DT1-weighted cervical images obtained at 3T MRI. Clinical disability was measured using the Expanded Disability Status Scale (EDSS), Nine-Hole-Peg test (9-HPT), and 25 feet Timed Walk Test (TWT). Stepwise linear regression was performed to assess the association between MUCCA and MRI measures, and between MUCCA and clinical disability. Results: MUCCA was smaller (mean 11.7%) in MS patients compared with healthy controls (72.56 +/- 9.82 and 82.24 +/- 7.80 mm(2) respectively; p<0.001), most prominently in male patients. MUCCA was associated with normalized brain volume, and number of cervical cord lesions. MUCCA was independently associated with EDSS, TWT, and 9-HPT. Conclusion: MUCCA was reduced in MS patients compared with healthy controls. It provides a relevant marker for clinical disability in long-standing disease, independent of other MRI measures.
引用
收藏
页码:1860 / 1865
页数:6
相关论文
共 22 条
  • [21] Gradient nonlinearity effects on upper cervical spinal cord area measurement from 3D T1-weighted brain MRI acquisitions
    Papinutto, Nico
    Bakshi, Rohit
    Bischof, Antje
    Calabresi, Peter A.
    Caverzasi, Eduardo
    Constable, R. Todd
    Datta, Esha
    Kirkish, Gina
    Nair, Govind
    Oh, Jiwon
    Pelletier, Daniel
    Pham, Dzung L.
    Reich, Daniel S.
    Rooney, William
    Roy, Snehashis
    Schwartz, Daniel
    Shinohara, Russell T.
    Sicotte, Nancy L.
    Stern, William A.
    Tagge, Ian
    Tauhid, Shahamat
    Tummala, Subhash
    Henry, Roland G.
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2018, 79 (03) : 1595 - 1601
  • [22] PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: A pilot study on relation to clinical findings and brain atrophy
    De Masi, R.
    Vergara, D.
    Pasca, S.
    Acierno, R.
    Greco, M.
    Spagnolo, L.
    Blasi, E.
    Sanapo, F.
    Trianni, G.
    Maffia, M.
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2009, 210 (1-2) : 80 - 86