Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)

被引：21
|
作者：
Vajs, V
Vugdelija, S
Trifunovic, S
Karadzic, I
Juranic, N
Macura, S
Milosavljevic, S
机构：
[1] Univ Belgrade, Fac Chem, YU-11001 Belgrade, Serbia
[2] Inst Chem Technol & Met, YU-11000 Belgrade, Serbia
[3] Sch Med, Dept Chem, YU-11001 Belgrade, Serbia
[4] Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA
来源：
FITOTERAPIA | 2003年 / 74卷 / 05期
关键词：
Hypericum perforatum; deoxyfurohyperforin A; antimicrobial activity;
D O I：
10.1016/S0367-326X(03)00114-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Repeated examination of the aerial parts of Hypericum Perfomtum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3-pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：439 / 444
页数：6
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