Effects of transforming growth factor alpha and hepatocyte growth factor on acid-induced damage in rat gastric epithelial cells

被引：0

作者：

Furukawa, O ^{[1
]}

Matsui, H

Suzuki, N

Okabe, S

机构：

[1] Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Kyoto 6078414, Japan

[2] Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, Ibaraki, Osaka 3058575, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 77卷 / 02期

关键词：

transforming growth factor alpha; cell protection; Na+/H+ exchanger;

D O I：

10.1254/jjp.77.173

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We examined the effects of transforming growth factor alpha (TGF-alpha) and hepatocyte growth factor (HGF) on acid-induced damage in a rat gastric epithelial cell line. Pretreatment of cells for 30 min with TGF-alpha, but not HGF, significantly prevented the acid-induced cell damage in a concentration-dependent manner. Genistein significantly reduced the protective effect of TGF-alpha. DNA synthesis in RGM1 cells was increased when the cells were incubated with TGF-alpha and HGF for 24 hr. We conclude that the protective effect of TGF-alpha against acid-induced damage seems to be caused by the activation of Na+/H+ exchangers and not by enhanced DNA synthesis.

引用

页码：173 / 176

页数：4