Effects of transforming growth factor alpha and hepatocyte growth factor on acid-induced damage in rat gastric epithelial cells

被引：0
|
作者：
Furukawa, O [1 ]
Matsui, H
Suzuki, N
Okabe, S
机构：
[1] Kyoto Pharmaceut Univ, Dept Appl Pharmacol, Kyoto 6078414, Japan
[2] Univ Tsukuba, Inst Clin Med, Dept Gastroenterol, Ibaraki, Osaka 3058575, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 77卷 / 02期
关键词：
transforming growth factor alpha; cell protection; Na+/H+ exchanger;
D O I：
10.1254/jjp.77.173
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We examined the effects of transforming growth factor alpha (TGF-alpha) and hepatocyte growth factor (HGF) on acid-induced damage in a rat gastric epithelial cell line. Pretreatment of cells for 30 min with TGF-alpha, but not HGF, significantly prevented the acid-induced cell damage in a concentration-dependent manner. Genistein significantly reduced the protective effect of TGF-alpha. DNA synthesis in RGM1 cells was increased when the cells were incubated with TGF-alpha and HGF for 24 hr. We conclude that the protective effect of TGF-alpha against acid-induced damage seems to be caused by the activation of Na+/H+ exchangers and not by enhanced DNA synthesis.
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页码：173 / 176
页数：4
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